Auer Ulrike, Mosing Martina
Clinic of Anaesthesiology and Perioperative Intensive Care, University of Veterinary Medicine Vienna, Vienna, Austria.
Vet Anaesth Analg. 2006 Jul;33(4):224-8. doi: 10.1111/j.1467-2995.2005.00262.x.
To evaluate the neuromuscular blocking and chronotropic effects of rocuronium bromide in cats anaesthetized for surgery.
Prospective clinical trial.
Twenty-two healthy cats of mixed breed presented for ovariectomy (n = 13) or castration (n = 9). Mean body mass (+/-SD) was 3.6 +/- 0.65 kg and mean age was 10.25 +/- 2.63 months.
Anaesthesia was induced with intravenous (IV) midazolam (0.3 mg kg(-1)), ketamine (3 mg kg(-1)) and butorphanol (0.4 mg kg(-1)). Tracheal intubation was performed and anaesthesia was maintained with isoflurane delivered in 100% oxygen. Neuromuscular function was monitored using acceleromyography applied at the ulnar nerve. This was stimulated by using the train-of-four (TOF) stimulus pattern (2 Hz) delivered every 15 seconds. The first train was made to establish baseline values for the first twitch (T1) and the TOF-ratio (T4:T1). Rocuronium (0.6 mg kg(-1) IV) was given and the following periods were recorded beginning at the end of injection: (1) lag time (LT) - to the first signs of T1 depression; (2) onset time (OT) - to the total ablation of T1; (3) duration of action (T1(25)) - to 25% recovery of the baseline value for T1; (4) T1(50)- to 50% baseline T1 restoration; (5) to TOF-ratios of 0.7 and 0.9. The time taken for T1 to recover from 75% to 25% depression (T1(25-75)) was also recorded. Heart rate (HR) was taken every minute for 15 minutes, beginning 5 minutes before rocuronium was injected.
Rocuronium (0.6 mg kg(-1)) had a mean LT of 15.0 +/- 0 seconds, OT of 46 +/- 11 seconds and T1(25) of 13.2 +/- 2.7 minutes. The mean time for TOF 0.7 and 0.9 was 17.3 +/- 5.4 and 20.7 +/- 5.4 minutes respectively. The mean T1(25-75) was 4.8 +/- 2.4 minutes. No significant changes in HR were observed at any of the time intervals recorded.
Rocuronium is an effective nondepolarizing muscle relaxant in the cat under the clinical conditions of this study. It has a rapid onset, a short duration of action and did not cause significant changes in HR.
评估在接受手术麻醉的猫中，罗库溴铵的神经肌肉阻滞和变时性效应。
前瞻性临床试验。
22只健康的混种猫，其中13只进行卵巢切除术，9只进行去势手术。平均体重（±标准差）为3.6±0.65千克，平均年龄为10.25±2.63个月。
通过静脉注射咪达唑仑（0.3毫克/千克）、氯胺酮（3毫克/千克）和布托啡诺（0.4毫克/千克）诱导麻醉。进行气管插管，并使用100%氧气输送的异氟醚维持麻醉。使用置于尺神经的加速度肌电图监测神经肌肉功能。每隔15秒采用四个成串刺激模式（2赫兹）进行刺激。进行第一次刺激以建立第一个肌颤搐（T1）和四个成串刺激比值（T4:T1）的基线值。静脉注射罗库溴铵（0.6毫克/千克），并从注射结束时开始记录以下时间段：（1）滞后时间（LT）——至T1出现抑制的首个迹象；（2）起效时间（OT）——至T1完全消失；（3）作用持续时间（T1(25)）——至T1基线值恢复25%；（4）T1(50)——至T1恢复至基线值的50%；（5）至四个成串刺激比值为0.7和0.9。还记录了T1从75%抑制恢复至25%抑制所需的时间（T1(25 - 75)）。在注射罗库溴铵前5分钟开始，每分钟记录心率（HR），共记录15分钟。
罗库溴铵（0.6毫克/千克）的平均滞后时间为15.0±0秒，起效时间为46±11秒，T1(25)为13.2±2.7分钟。四个成串刺激比值为0.7和0.9的平均时间分别为17.3±5.4分钟和20.7±5.4分钟。平均T1(25 - 75)为4.8±2.4分钟。在记录的任何时间间隔内，均未观察到心率有显著变化。
在本研究的临床条件下，罗库溴铵是猫有效的非去极化肌肉松弛剂。它起效迅速，作用持续时间短，且未引起心率显著变化。
