Alderson Briony, Senior J Mark, Jones Ronald S, Dugdale Alexandra H A
The University of Liverpool Small Animal Referral Hospital, Liverpool, UK.
Vet Anaesth Analg. 2007 Jul;34(4):251-6. doi: 10.1111/j.1467-2995.2006.00307.x. Epub 2007 May 8.
A clinical trial to determine whether continuous infusion administration technique was suitable for maintaining neuromuscular blockade with rocuronium bromide in dogs.
Twenty-two dogs, 10 males and 12 females, median age 2 years 4 months, median weight 32 kg undergoing elective surgical procedures under general anaesthesia: ASA classification I or II.
After induction of anaesthesia, neuromuscular function was evaluated using train-of-four (TOF) stimulation of the dorsal buccal branch of the facial nerve. A bolus dose of 0.5 mg kg(-1) rocuronium was administered intravenously and an infusion of 0.2 mg kg(-1) hour(-1) was started immediately. Neuromuscular blockade was assessed visually by counting the number of twitches observed during TOF stimulation repeated at 10-second intervals.
The bolus dose of rocuronium abolished the response to TOF stimulation in 21 of the 22 dogs. The median onset time of neuromuscular blockade (complete loss of all four twitches) was 82 seconds (range 38-184 seconds). Median infusion duration was 76 minutes (range 20.3-146 minutes).
This protocol of rocuronium administration was considered to be effective in dogs. Constant infusion of rocuronium is easily applicable to clinical practice and further work is required on infusion titration.
进行一项临床试验，以确定持续输注给药技术是否适用于维持犬溴化罗库溴铵的神经肌肉阻滞作用。
22只犬，10只雄性，12只雌性，中位年龄2岁4个月，中位体重32 kg，在全身麻醉下接受择期外科手术：美国麻醉医师协会（ASA）分级为I或II级。
麻醉诱导后，通过对面神经颊背支进行四个成串刺激（TOF）来评估神经肌肉功能。静脉注射0.5 mg·kg⁻¹的溴化罗库溴铵负荷剂量，并立即开始以0.2 mg·kg⁻¹·小时⁻¹的速度输注。每隔10秒重复进行TOF刺激，通过目视计数观察到的抽搐次数来评估神经肌肉阻滞情况。
22只犬中有21只犬在注射溴化罗库溴铵负荷剂量后对TOF刺激的反应消失。神经肌肉阻滞的中位起效时间（所有四个抽搐完全消失）为82秒（范围38 - 184秒）。中位输注持续时间为76分钟（范围20.3 - 146分钟）。
该溴化罗库溴铵给药方案在犬中被认为是有效的。持续输注溴化罗库溴铵易于应用于临床实践，还需要进一步开展输注滴定方面的研究。
