Cao D, Börjesson O, Larsson P, Rudin A, Gunnarsson I, Klareskog L, Malmström V, Trollmo C
Rheumatology Unit, Department of Medicine at Karolinska University Hospital Solna, Karolinska Institutet, Stockholm.
Scand J Immunol. 2006 Jun;63(6):444-52. doi: 10.1111/j.1365-3083.2006.001755.x.
Regulatory T cells have recently been implicated in a number of human diseases, including rheumatoid arthritis. To investigate whether the presence of CD25+CD4+ regulatory T cells is a general finding in arthritic joints, synovial fluid of patients with different rheumatic diseases such as undifferentiated arthritides, systemic rheumatic diseases and reactive arthritis were investigated for the presence of such cells. In 95% of the patients, a higher frequency of CD25(bright)CD4+ T cells was found in synovial fluid as compared with peripheral blood. Both in vitro suppression experiments and FOXP3 mRNA analysis confirmed these cells to be natural regulatory T cells. Together with our previous data, we conclude that arthritic joints, irrespective of precise diagnosis and disease duration, are enriched with natural regulatory T cells. These results suggest that suppressor cells migrate to and/or multiply at the sites of inflammation as part of the immune responses' effort to combat injurious inflammation.
调节性T细胞最近被认为与包括类风湿性关节炎在内的多种人类疾病有关。为了研究CD25+CD4+调节性T细胞的存在是否是关节炎关节中的普遍现象，我们对患有不同风湿性疾病（如未分化关节炎、系统性风湿性疾病和反应性关节炎）的患者的滑液进行了研究，以检测此类细胞的存在情况。在95%的患者中，与外周血相比，滑液中CD25（明亮）CD4+T细胞的频率更高。体外抑制实验和FOXP3 mRNA分析均证实这些细胞是天然调节性T细胞。结合我们之前的数据，我们得出结论，无论精确诊断和疾病持续时间如何，关节炎关节中都富含天然调节性T细胞。这些结果表明，作为免疫反应对抗有害炎症努力的一部分，抑制性细胞迁移到炎症部位并/或在炎症部位增殖。
