Taban Mehran, Dupps William J, Mandell Brian, Perez Victor L
Uveitis and Cornea Services, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Ocul Immunol Inflamm. 2006 Jun;14(3):145-50. doi: 10.1080/09273940600659393.
To report a case of severe anterior uveitis flare following the administration of etanercept (Enbrel) for ankylosing spondylitis and to review the literature pertaining to inflammatory eye disease associated with the use of etanercept.
Clinical data were collected from a 52-year-old female with chronic symptomatic ankylosing spondylitis. The relationship between etanercept administration and the patient's systemic and ocular inflammation was assessed. A review of the literature was conducted to identify additional reports.
A patient with a history of ankylosing spondylitis exhibited acute exacerbations of uveitis that were temporally related to etanercept injections. Re-challenge was associated temporally with a worsening of symptoms, and drug withdrawal, in concert with aggressive systemic steroid treatment, resulted in rapid resolution. Seventeen cases of inflammatory eye disease (uveitis, scleritis, orbital myositis) believed to be associated with etanercept therapy were found in the recent literature.
Ocular inflammation is paradoxically a potential adverse event following the use of etanercept in both previously uninvolved and inflamed eyes. Careful surveillance of patients on etanercept is warranted to assure that flares in ocular inflammation are not secondary to etanercept therapy.
报告1例强直性脊柱炎患者使用依那西普（恩利）后发生严重前葡萄膜炎发作的病例，并复习与使用依那西普相关的炎性眼病的文献。
收集1例52岁慢性症状性强直性脊柱炎女性患者的临床资料。评估依那西普给药与患者全身及眼部炎症之间的关系。进行文献复习以找出更多报告。
1例有强直性脊柱炎病史的患者出现葡萄膜炎急性加重，在时间上与依那西普注射有关。再次使用依那西普在时间上与症状恶化相关，停药并联合积极的全身类固醇治疗后症状迅速缓解。近期文献中发现17例据信与依那西普治疗相关的炎性眼病（葡萄膜炎、巩膜炎、眼眶肌炎）。
矛盾的是，眼部炎症是使用依那西普后在既往未受累及已发炎的眼睛中均可能出现的不良事件。对使用依那西普的患者进行仔细监测，以确保眼部炎症发作并非依那西普治疗的继发反应。
