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拿破仑·齐布尔斯基——波兰开发血流速度测量装置的先驱。

Napoleon Cybulski--Polish pioneer in developing of the device for measuring blood flow velocity.

作者信息

Pawlik W W, Konturek S J, Bilski R

机构信息

Chair of Physiology, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland.

出版信息

J Physiol Pharmacol. 2006 Apr;57 Suppl 1:107-18.

Abstract

Napoleon Cybulski (1854-1919) was the most prominent Polish physiologist who chaired the Department of Physiology at the Faculty of Medicine of Jagiellonian University between 1885 and 1919. One of his greatest achievements was the construction of a device for precise measurements of blood movement in the vessels - the photohemotachometer, which provided a better insight into the physiology and pathophysiology of the circulatory system. In the field of endocrinology Cybulski together with Szymonowicz, found out that adrenal extracts contain biologically active substances that elevate blood pressure. He was also a constructor of an extremely clever microcalorimeter to measure the quantity of heat produced during isolated muscle contraction. He applied, for the first time, condensator discharges to stimulate nerves and analyzed changes in the excitability of the muscles. Cybulski proved that the cause of the electrical excitability of tissue depends on the electrical energy and the time of its duration. Together with Beck, he performed the experiments on the sensory centers in the central nervous system by means of the observations of the electrical evoked potentials. They discovered the continuous electrical oscillations in the brain - the brain waves and recorded the negative electrical potentials in certain brain areas induced by sensory impulses coming from the periphery. Using this technique Beck and Cybulski localized various centers in the brain of dogs and Macaccus rhesus monkeys. The names of Beck and Cybulski were quoted in many publications on neurophysiology and electroencephalography. The present paper describes Napoleon Cybulski as a constructor of an original instrument for studying the movement of blood under various experimental conditions an emphasizes the contribution of this invention to the development of physiology.

摘要

拿破仑·齐布尔斯基(1854 - 1919)是最杰出的波兰生理学家,1885年至1919年期间担任雅盖隆大学医学院生理学系主任。他最伟大的成就之一是构建了一种用于精确测量血管中血液流动的装置——光血速度计,这为深入了解循环系统的生理学和病理生理学提供了更好的视角。在内分泌学领域,齐布尔斯基与西蒙诺维茨一起发现肾上腺提取物含有能升高血压的生物活性物质。他还是一种极其精巧的微热量计的发明者,用于测量离体肌肉收缩过程中产生的热量。他首次应用电容器放电来刺激神经,并分析肌肉兴奋性的变化。齐布尔斯基证明组织电兴奋性的原因取决于电能及其持续时间。他与贝克一起通过观察电诱发电位对中枢神经系统的感觉中枢进行了实验。他们发现了大脑中的持续电振荡——脑电波,并记录了由来自外周的感觉冲动在某些脑区诱发的负电位。利用这项技术,贝克和齐布尔斯基在狗和恒河猴的大脑中定位了各个中枢。贝克和齐布尔斯基的名字在许多关于神经生理学和脑电图学的出版物中被引用。本文将拿破仑·齐布尔斯基描述为一种用于在各种实验条件下研究血液流动的原创仪器的发明者,并强调了这项发明对生理学发展的贡献。

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