De Martino Benedetto, Strange Bryan A, Dolan Raymond J
Functional Imaging Laboratory, Institute of Neurology, Wellcome Trust Centre for Neuroimaging, 12 Queen Square, London, WC1N 3BG, UK.
Psychopharmacology (Berl). 2008 Mar;197(1):127-36. doi: 10.1007/s00213-007-1015-5. Epub 2007 Nov 30.
Norepinephrine (NE) has a regulatory role in human attention.
To examine its role in emotional modulation of attention, we used an attentional blink (AB) paradigm, in the context of psychopharmacological manipulation, where targets were either emotional or neutral items.
We report behavioural evidence that beta-adrenergic blockade with propranolol impairs attention independent of target valence. Furthermore, this effect is centrally mediated as administration of the peripheral beta-adrenergic antagonist nadolol did not impair attention. By contrast, increasing NE tone, using the selective NE reuptake inhibitor reboxetine, improves detection of emotional stimuli.
In line with theoretical and animal models, these findings provide human behavioural evidence that the adrenergic system has a modulatory influence on selective attention that in some instances depends on item valence.
去甲肾上腺素（NE）在人类注意力方面具有调节作用。
为研究其在注意力的情绪调节中的作用，我们在心理药理学操纵的背景下使用了注意瞬脱（AB）范式，其中目标刺激为情绪性或中性项目。
我们报告了行为学证据，即普萘洛尔进行的β-肾上腺素能阻断会损害注意力，且与目标效价无关。此外，这种效应是由中枢介导的，因为外周β-肾上腺素能拮抗剂纳多洛尔的给药并未损害注意力。相比之下，使用选择性NE再摄取抑制剂瑞波西汀增加NE水平，可改善对情绪刺激的检测。
与理论和动物模型一致，这些发现提供了人类行为学证据，表明肾上腺素能系统对选择性注意力具有调节作用，在某些情况下取决于项目效价。
