Nagai Yayoi, Yamanaka Masayoshi, Nishimura Shigeru, Nakano Akihiko, Hasegawa Akira, Ishikawa Osamu
Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, 371-8511, Japan.
Mod Rheumatol. 2006;16(3):188-90. doi: 10.1007/s10165-006-0477-3.
We present the case of a 60-year-old female patient with systemic sclerosis complicated by pulmonary hypertension. Ten days after the initiation of treatment with bosentan, high fever and skin eruptions were noted. In the previous reports, the frequency of drug-induced skin eruptions has not been well documented. Since the use of bosentan is expected to increase, we should be aware of the previously unknown adverse effects as well as skin eruptions.
我们报告一例60岁女性患者，患有系统性硬化症并伴有肺动脉高压。在开始使用波生坦治疗10天后，出现了高热和皮疹。在以往的报告中，药物性皮疹的发生率尚无充分记录。鉴于波生坦的使用预计会增加，我们应该意识到此前未知的不良反应以及皮疹。
