波生坦治疗的患者加用甲氨蝶呤后出现严重肝毒性：停用波生坦后恢复甲氨蝶呤治疗，肝毒性可逆转。 - Suppr

Severe hepatotoxicity in a patient on bosentan upon addition of methotrexate: reversible with resumption of methotrexate without bosentan.

Dwyer Nathan, Jones Graeme, Kilpatrick David

Department of Cardiology, Royal Hobart Hospital, Tasmania, Australia.

J Clin Rheumatol. 2009 Mar;15(2):88-9. doi: 10.1097/RHU.0b013e31819bc71f.

Abstract

摘要

J Clin Rheumatol. 2009 Mar;15(2):88-9. doi: 10.1097/RHU.0b013e31819bc71f.

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N Engl J Med. 2006 May 18;354(20):2191-3; author reply 2191-3.

Ann Card Anaesth. 2008 Jul-Dec;11(2):138; author reply 138-9. doi: 10.4103/0971-9784.41593.

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