Rosenzweig Mary, Nielsen Anna Sophie Toftlund
Laegemiddelstyrelsen, Afdeling Laegemiddeløkonomi, København S.
Ugeskr Laeger. 2006 May 15;168(20):1975-81.
The purpose of this survey was to map the sale of analgesics in the Danish primary care sector from 2000 to 2004.
Data on analgesics and NSAIDs were drawn from the Register of Medicinal Products Statistics. Sales in 2004 and changes from 2000 to 2004 are treated with descriptive statistics. Our focus was on analgesics bought on prescription.
In 2004, approximately 580,000 persons bought an analgesic on prescription. Including NSAIDs it is a total of approximately 1.16 million people. Between 2000 and 2004, the number of users increased by 10%. STRONG OPIOIDS: The number of users was almost unchanged from 2000 to 2004. Most people bought ketobemidone and morphine, even though the number of these users decreased. In contrast, the number of oxycodone users increased greatly. Several-time users of oxycodone are often new users of strong opioids. Likewise, the number of users of transdermal fentanyl and buprenorphine patches increased. WEAK OPIOIDS: The number of users increased by approximately 31,000 (10%), due to a greater number of users of tramadol, while the number of users of other weak opioids decreased. Thirty percent of several-time users of tramadol had not previously bought other analgesics on prescription. NSAIDs: The number of users increased by approximately 95,000 (13%). After 2002, the number of coxib users decreased concurrently with an increased usage of other NSAIDs. After coxib treatment, 29% of several-time users did not shift to other analgesics bought on prescription. WEAK NON-OPIOIDS: The number of users increased by approximately 42,000 (15%). The majority were users of paracetamol.
In 2004, every fifth Danish citizen bought analgesics on prescription. Between 2000 and 2004, the number increased. In particular, the number of users of NSAIDs was large. The number of users of strong opioids did not increase as did the number of users of the other groups of analgesics, but within that group there was a shift to more expensive drugs.
本次调查的目的是绘制2000年至2004年丹麦初级医疗部门镇痛药的销售情况。
镇痛药和非甾体抗炎药的数据取自药品统计登记册。对2004年的销售额以及2000年至2004年的变化进行描述性统计分析。我们关注的是凭处方购买的镇痛药。
2004年，约58万人凭处方购买了镇痛药。包括非甾体抗炎药在内，总共有约116万人。2000年至2004年期间，用户数量增加了10%。强效阿片类药物：2000年至2004年期间，用户数量几乎没有变化。大多数人购买了凯托米酮和吗啡，尽管这些用户的数量有所减少。相比之下，羟考酮用户的数量大幅增加。多次使用羟考酮的用户往往是强效阿片类药物的新用户。同样，透皮芬太尼和丁丙诺啡贴剂的用户数量也增加了。弱效阿片类药物：用户数量增加了约3.1万（10%），这是由于曲马多的用户数量增加，而其他弱效阿片类药物的用户数量减少。30%多次使用曲马多的用户此前未曾凭处方购买过其他镇痛药。非甾体抗炎药：用户数量增加了约9.5万（13%）。2002年之后，环氧化酶抑制剂用户数量减少，与此同时其他非甾体抗炎药的使用量增加。在使用环氧化酶抑制剂治疗后，29%多次使用的用户没有转而购买其他凭处方购买的镇痛药。弱效非阿片类药物：用户数量增加了约4.2万（15%）。大多数是对乙酰氨基酚的用户。
2004年，每五名丹麦公民中就有一人凭处方购买镇痛药。2000年至2004年期间，数量有所增加。特别是，非甾体抗炎药的用户数量众多。强效阿片类药物的用户数量没有像其他镇痛药组的用户数量那样增加，但在该组内出现了转向更昂贵药物的情况。
