Sizonenko Stéphane V, Borradori-Tolsa Cristina, Bauthay Delphine M, Lodygensky Gregory, Lazeyras François, Hüppi Petra
Department of Pediatrics, Geneva University Hospital, Switzerland.
Mol Cell Endocrinol. 2006 Jul 25;254-255:163-71. doi: 10.1016/j.mce.2006.04.035.
There are now a number of evidences showing that the developing organism adapts to the environment it finds itself. Short- and long-term adjustments, referred as "programming", take place and will initially induce intrauterine growth retardation but will also have consequences that will appear later in life. The use of magnetic resonance imaging (MRI) techniques in IUGR babies has delineated changes in the central nervous system (CNS) development that correlate with altered neurodevelopment and could be implicated in the development of neuropsychiatric disorders in adult life. Similarly, the use of corticosteroid treatment in preterm infants has also been implicated in abnormal CNS development. In this review, we will focus on the modifications of CNS development that occur after exposition to adverse environment such as undernutrition or corticosteroid treatment that can now be studied in vivo with advanced MRI technology.
现在有许多证据表明，发育中的生物体能够适应其所处的环境。被称为“编程”的短期和长期调整会发生，最初会导致宫内生长迟缓，但也会产生在生命后期才会显现的后果。在宫内生长受限（IUGR）婴儿中使用磁共振成像（MRI）技术已经描绘出中枢神经系统（CNS）发育的变化，这些变化与神经发育改变相关，并且可能与成年后神经精神疾病的发生有关。同样，在早产儿中使用皮质类固醇治疗也与中枢神经系统异常发育有关。在这篇综述中，我们将重点关注暴露于诸如营养不良或皮质类固醇治疗等不利环境后中枢神经系统发育的改变，现在可以使用先进的MRI技术在体内对这些改变进行研究。
