1 Victorian Infant Brain Studies, Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.
J Int Neuropsychol Soc. 2013 Nov;19(10):1065-75. doi: 10.1017/S1355617713000891. Epub 2013 Aug 15.
Using magnetic resonance imaging, this study compared hippocampal volume between 145 very preterm children and 34 children born full-term at 7 years of age. The relationship between hippocampal volume and memory and learning impairments at 7 years was also investigated. Manual hippocampal segmentation and subsequent three-dimensional volumetric analysis revealed reduced hippocampal volumes in very preterm children compared with term peers. However, this relationship did not remain after correcting for whole brain volume and neonatal brain abnormality. Contrary to expectations, hippocampal volume in the very preterm cohort was not related to memory and learning outcomes. Further research investigating the effects of very preterm birth on more extensive networks in the brain that support memory and learning in middle childhood is needed.
本研究采用磁共振成像技术，对 145 名极早产儿和 34 名足月出生的儿童进行了 7 岁时海马体积的比较。还研究了海马体积与 7 岁时记忆和学习障碍之间的关系。手动海马分割和随后的三维容积分析显示，极早产儿的海马体积小于足月同龄人。然而，在纠正全脑体积和新生儿脑异常后，这种关系就不存在了。与预期相反，极早产儿组的海马体积与记忆和学习结果无关。需要进一步研究极早产儿出生对支持儿童中期记忆和学习的更广泛大脑网络的影响。
