Sizonenko S V, Borradori-Tolsa C, Hüppi P S
Service du développement et de la croissance, Département de l'enfant et de l'adolescent, HUG, Genève.
Rev Med Suisse. 2008 Feb 27;4(146):509-10, 512-4.
Evidence exists that the developing organism adapts to the environment it finds itself. Short and long-term adjustments take place and will initially induce intrauterine growth retardation but will also have consequences that will appear later in life. These adjustments are referred as "programming". The use of advanced magnetic resonance imaging techniques in IUGR babies has delineated changes in the development of the central nervous system that correlate with altered neurodevelopment and could be implicated in the development of neuropsychiatric disorders in adult life. In this review, we will delineate some modifications of CNS development and functions that occur after exposition to adverse environment and that can now be studied in vivo with advanced imaging technology.
有证据表明，发育中的生物体能够适应其所处的环境。会发生短期和长期的调整，这些调整最初会导致宫内生长迟缓，但也会产生在生命后期才会显现的后果。这些调整被称为“编程”。在宫内生长受限婴儿中使用先进的磁共振成像技术已经描绘出中枢神经系统发育的变化，这些变化与神经发育改变相关，并且可能与成年后神经精神疾病的发生有关。在这篇综述中，我们将描绘在暴露于不利环境后中枢神经系统发育和功能的一些改变，现在可以使用先进的成像技术在体内对这些改变进行研究。
