Abir Farshad, Alva Suraj, Longo Walter E, Audiso Riccardo, Virgo Katherine S, Johnson Frank E
Department of Surgery, Yale School of Medicine, P.O. Box 208062, New Haven, CT 06520-8062, USA.
Am J Surg. 2006 Jul;192(1):100-8. doi: 10.1016/j.amjsurg.2006.01.053.
Colon cancer is relatively common; however, the results of treatment have marginally improved over the last half century. Though about 85% of patients have colorectal tumors resected with curative intent, a significant number of these patients will eventually die from cancer. As a result, many clinicians have advocated intensive follow-up in such patients as an attempt to increase survival.
A review of the literature focusing on studies that have specifically addressed postoperative surveillance programs in patients with colorectal cancer was conducted. Only studies with level A evidence were included. Further references were obtained through cross-referencing the bibliography cited in each work.
One of the six prospective randomized studies demonstrated a statistically significant survival benefit. Undoubtedly, survival benefits can be shown with a well-designed evidence-based follow-up strategy. However, well-designed large prospective multi-institutional randomized studies are needed to establish a consensus for follow-up.
结肠癌相对常见；然而，在过去半个世纪里，治疗结果仅略有改善。尽管约85%的患者接受了旨在治愈的结直肠肿瘤切除术，但这些患者中有相当一部分最终会死于癌症。因此，许多临床医生主张对这类患者进行强化随访，以期提高生存率。
对专门针对结直肠癌患者术后监测方案的研究进行了文献综述。仅纳入了具有A级证据的研究。通过交叉引用每项研究中引用的参考文献获取了更多参考文献。
六项前瞻性随机研究中的一项显示出具有统计学意义的生存获益。毫无疑问，精心设计的循证随访策略可以显示出生存获益。然而，需要精心设计的大型前瞻性多机构随机研究来建立随访的共识。
