Ebisawa Y, Miyaji F, Kokubo T, Ohura K, Nakamura T
Faculty of Engineering, Kyoto University, Japan.
Biomaterials. 1997 Oct;18(19):1277-84. doi: 10.1016/s0142-9612(97)00067-7.
Bioactive and ferrimagnetic glass-ceramics are useful as thermoseeds for hyperthermia treatment of cancer. A heat treatment of a 40(FeO, Fe2O3)-60CaO x SiO2 wt% glass gives a ferrimagnetic glass-ceramic containing 36 wt% magnetite in a CaO x SiO2 matrix. However, it does not show bioactivity since a small amount of iron ion remains in the matrix. In the present study, bioactivities of ferrimagnetic glass-ceramics which were prepared by heat treatment of glasses of the composition 40(FeO, Fe2O3)-60CaO x SiO2 (wt%) with various components added at 100:3 weight ratio were evaluated in vitro by examining bone-like apatite formation on their surfaces in a simulated body fluid. It was found that glass-ceramics with Na2O or B2O3 added in combination with P2O5 show bioactivity.
生物活性和亚铁磁性玻璃陶瓷可用作癌症热疗的热种子。对40（FeO、Fe₂O₃）-60CaO x SiO₂ 重量百分比的玻璃进行热处理，可得到一种在CaO x SiO₂ 基体中含有36重量百分比磁铁矿的亚铁磁性玻璃陶瓷。然而，由于少量铁离子残留在基体中，它不显示生物活性。在本研究中，通过在模拟体液中检查其表面上骨样磷灰石的形成，体外评估了通过对40（FeO、Fe₂O₃）-60CaO x SiO₂（重量百分比）组成的玻璃添加各种成分（重量比为100:3）进行热处理制备的亚铁磁性玻璃陶瓷的生物活性。发现添加了Na₂O或B₂O₃并与P₂O₅ 结合的玻璃陶瓷具有生物活性。
