Guven M A, Kilinc M, Batukan C, Ekerbicer H C, Aksu T
School of Medicine, Department of Obstetrics and Gynecology, Kahramanmaras Sutcu Imam University, Yenisehir Mh., Cumhuriyet Blv., Gunes Apt., #14/18, 46100, Kahramanmaras, Turkey.
Arch Gynecol Obstet. 2006 Oct;274(6):333-7. doi: 10.1007/s00404-006-0191-6. Epub 2006 Jun 13.
Our aim was to investigate the association between total serum homocysteine, vitamin B12 and folate levels in pregnant women with gestational diabetes mellitus (GDM), glucose intolerance and compare them with those of glucose tolerant pregnant women.
Serum homocysteine, vitamin B12 and serum folate levels were prospectively measured in a total of 223 pregnant women who were grouped according to their status of glucose tolerance as gestational diabetes (abnormal 1-h and 3-h glucose tolerance test; n = 30), glucose intolerant (abnormal 1-h, but normal 3-h glucose tolerance test; n = 46) or normal controls (normal 1-h glucose test; n = 147).
Mean serum homocysteine concentration of women in gestational diabetes, glucose intolerants and normal controls at 24-28 weeks of gestation was 9.0 +/- 3.1, 8.1 +/- 2.5 and 7.4 +/- 1.6 micromol/l, respectively. The only statistically difference in homocysteine levels was observed between women with gestational diabetes and normal controls (P < 0.01). However, no difference was observed for vitamin B12 and folate levels.
Second trimester serum homocysteine concentrations are higher among women with GDM, as compared to normal controls.
我们的目的是研究妊娠糖尿病（GDM）孕妇、糖耐量异常孕妇血清总同型半胱氨酸、维生素B12和叶酸水平之间的关联，并将其与糖耐量正常的孕妇进行比较。
前瞻性地测定了总共223名孕妇的血清同型半胱氨酸、维生素B12和血清叶酸水平，这些孕妇根据糖耐量状况分为妊娠糖尿病组（1小时和3小时糖耐量试验异常；n = 30）、糖耐量异常组（1小时糖耐量试验异常，但3小时糖耐量试验正常；n = 46）或正常对照组（1小时糖耐量试验正常；n = 147）。
妊娠糖尿病组、糖耐量异常组和正常对照组孕妇在妊娠24 - 28周时的血清同型半胱氨酸平均浓度分别为9.0±3.1、8.1±2.5和7.4±1.6微摩尔/升。同型半胱氨酸水平仅在妊娠糖尿病组和正常对照组之间存在统计学差异（P < 0.01）。然而，维生素B12和叶酸水平未观察到差异。
与正常对照组相比，GDM孕妇孕中期血清同型半胱氨酸浓度更高。
