Sun Wei, Yan Yongnian, Lin Feng, Spector Myron
Mechanical Engineering and Mechanics, Drexel University, Philadelphia, Pennsylvania, USA.
Tissue Eng. 2006 May;12(5):1169-81. doi: 10.1089/ten.2006.12.1169.
A recent US-China National Science Foundation-sponsored workshop on biomanufacturing reviewed the state-of-the-art of an array of new technologies for producing scaffolds for tissue engineering, providing precision multi-scale control of material, architecture, and cells. One broad category of such techniques has been termed solid freeform fabrication. The techniques in this category include: stereolithography, selected laser sintering, single- and multiple-nozzle deposition and fused deposition modeling, and three-dimensional printing. The precise and repetitive placement of material and cells in a three-dimensional construct at the micrometer length scale demands computer control. These novel computer-controlled scaffold production techniques, when coupled with computer-based imaging and structural modeling methods for the production of the templates for the scaffolds, define an emerging field of computer-aided tissue engineering. In formulating the questions that remain to be answered and discussing the knowledge required to further advance the field, the Workshop provided a basis for recommendations for future work.
最近，由美中两国国家科学基金会赞助的一次生物制造研讨会，回顾了一系列用于生产组织工程支架的新技术的现状，这些技术能对材料、结构和细胞进行精确的多尺度控制。这类技术中的一大类被称为实体自由成型制造。这一类别中的技术包括：立体光刻、选择性激光烧结、单喷嘴和多喷嘴沉积以及熔融沉积成型，还有三维打印。在微米长度尺度上，在三维结构中精确且重复地放置材料和细胞需要计算机控制。这些新颖的计算机控制支架生产技术，与用于生产支架模板的基于计算机的成像和结构建模方法相结合，定义了一个新兴的计算机辅助组织工程领域。在提出有待解答的问题并讨论进一步推动该领域发展所需的知识时，本次研讨会为未来工作的建议提供了基础。
