Wagner H
Department of Pharmacy, Center for Pharmaresearch, Ludwig-Maximilians-University, Butenandtstrasse 5-13, 81377 Munich, Germany.
Phytomedicine. 2006;13 Suppl 5:122-9. doi: 10.1016/j.phymed.2006.03.021. Epub 2006 Jun 12.
Since many years the concept of classical phytotherapy using herbal drug combinations with superior efficacy and lesser side effects in comparison with single isolated constituents of plant extracts has been repeatedly assessed clinically as well as pharmacologically. For this as multitarget therapy defined treatment lot of examples are presented. The exact mechanisms of action underlying these synergy effects is unknown. It could be explained by a multitarget action of compounds on a molecular level or partly by an improved resorption rate and a change of pharmacokinetic. Progress in the field of drug synergy research may lend with standardized plant extracts a new legitimacy and may open the chance to use extract combinations for the treatment of diseases which previously have been reserved for chemotherapeutics only.
多年来，与植物提取物的单一分离成分相比，使用具有更高疗效和更少副作用的草药组合进行经典植物疗法的概念在临床和药理学方面都得到了反复评估。作为多靶点疗法定义的治疗方法，有很多这样的例子。这些协同效应背后的确切作用机制尚不清楚。这可以通过化合物在分子水平上的多靶点作用来解释，或者部分是由于吸收速率的提高和药代动力学的改变。药物协同研究领域的进展可能会为标准化植物提取物带来新的合理性，并可能为使用提取物组合治疗以前仅用化学疗法治疗的疾病提供机会。
