Seavers A, Snow D H, Mason K V, Malik R
Oak Flats Veterinary Clinic, Oak Flats, New South Wales 2529, Australia.
Aust Vet J. 2008 Nov;86(11):429-34. doi: 10.1111/j.1751-0813.2008.00357.x.
To determine the thyroid status of Basenji dogs in Australia.
Jugular or cephalic venipuncture blood samples were taken from 113 Basenji, comprising 47 males, 5 castrates, 48 entire and 13 spayed bitches, and sent on ice in plain and EDTA tubes to a single laboratory to determine haematocrit and serum concentrations of total thyroid hormone (thyroxine, TT4), thyroid-stimulating hormone (TSH) and cholesterol. In a subgroup of 8 dogs with abnormal elevated TSH concentrations and subnormal TT4 concentrations, 5 were further examined by dynamic endocrine testing using recombinant human (rh) TSH (54 microg).
Ages ranged from 1 to 14 years and weight range was 6.5 to 14.0 kg. TT4 concentrations (nmol/L) ranged from 2 to 27, with a median of 13 and a mean +/- SD of 13.0 +/- 5.7. Importantly, 85/113 (75%) of TT4 values were lower than the normal laboratory reference range (17-37). TSH concentrations (ng/mL) ranged from 0.05 to 5.37, with a median of 0.16 and a mean +/- SD of 0.3 +/- 0.6.
Basenji have a similar reference range for serum TSH, but a considerably lower reference range for TT4 (2-27 nmol/L) than most breeds and crossbreds, resembling the sight hounds in this respect. Given the difficulty of accurately measuring TT4 concentrations that are so low, concomitant serial TSH determinations are essential to properly asses thyroid function. Taken alone, TT4 determinations are only of use when the value is within the reference range, in which case a diagnosis of hypothyroidism is likely excluded.
确定澳大利亚巴仙吉犬的甲状腺状态。
从113只巴仙吉犬采集颈静脉或头静脉血样，其中包括47只雄性、5只去势犬、48只未绝育犬和13只绝育母犬，血样置于冰上，分别装在普通管和乙二胺四乙酸（EDTA）管中，送至单一实验室，以测定血细胞比容以及血清中总甲状腺激素（甲状腺素，TT4）、促甲状腺激素（TSH）和胆固醇的浓度。在8只促甲状腺激素浓度异常升高且甲状腺素浓度低于正常水平的犬亚组中，5只犬通过使用重组人（rh）促甲状腺激素（54微克）进行动态内分泌检测作进一步检查。
年龄范围为1至14岁，体重范围为6.5至14.0千克。TT4浓度（纳摩尔/升）范围为2至27，中位数为13，平均值±标准差为13.0±5.7。重要的是，113只犬中有85只（75%）的TT4值低于实验室正常参考范围（17 - 37）。TSH浓度（纳克/毫升）范围为0.05至5.37，中位数为0.16，平均值±标准差为0.3±0.6。
巴仙吉犬血清TSH的参考范围相似，但TT4的参考范围（2 - 27纳摩尔/升）比大多数品种和杂交品种低得多，在这方面与视觉猎犬相似。鉴于准确测量如此低的TT4浓度存在困难，同时进行连续的TSH测定对于正确评估甲状腺功能至关重要。单独检测时，只有当TT4值在参考范围内时才有意义，此时可能排除甲状腺功能减退的诊断。
