Barnes D M, Meyer J S, Gonzalez J G, Gullick W J, Millis R R
ICRF Clinical Oncology Unit, Guy's Hospital, London, UK.
Breast Cancer Res Treat. 1991 Mar;18(1):11-7. doi: 10.1007/BF01975438.
The relationship between the presence of the c-erbB-2 protein, demonstrated immunohistochemically with antibody 21N, and thymidine labelling index (TLI) has been studied in the in situ component of 70 cases of carcinoma of the breast. A significant association was found between high TLI and positive staining. Twenty of the 70 cases stained (29%) and of those that were stained 75% had a high TLI; 43% of those with a high TLI stained positively but only 14% of those with a low TLI stained positively. Strong correlations were seen between nuclear size and histological pattern and both 21N staining and TLI. The majority of carcinomas of comedo pattern with large nuclei were 21N positive and had a high TLI, whilst those with small nuclei and a predominantly cribriform/micropapillary appearance did not stain and had a low TLI. In tumours of mixed histological pattern there was less concordance between staining and TLI. The significance of these findings in relation to the biological behaviour of these tumours and their clinical management is discussed.
运用抗体21N通过免疫组织化学方法检测了70例乳腺癌原位成分中c-erbB-2蛋白的表达，并研究了其与胸腺嘧啶核苷标记指数（TLI）之间的关系。结果发现高TLI与阳性染色之间存在显著关联。70例中有20例染色阳性（29%），在这些染色阳性的病例中，75%具有高TLI；高TLI病例中有43%染色阳性，而低TLI病例中只有14%染色阳性。核大小与组织学类型以及21N染色和TLI之间均存在强相关性。大多数具有大核的粉刺型癌21N呈阳性且TLI高，而那些具有小核且主要呈筛状/微乳头外观的癌不染色且TLI低。在混合组织学类型的肿瘤中，染色与TLI之间的一致性较差。讨论了这些发现与这些肿瘤生物学行为及其临床管理的相关性。
