Falagas M E, Apostolou K E, Pappas V D
Alfa Institute of Biomedical Sciences (AIBS), 9 Neapoleos Street, Athens, Marousi, 15123, Greece.
Eur J Clin Microbiol Infect Dis. 2006 Jul;25(7):419-25. doi: 10.1007/s10096-006-0159-2.
A systematic review of matched cohort and case-control studies was performed to examine the mortality attributable to candidemia. The review included studies that compared mortality of patients with candidemia (cases) to that of matched patients without candidemia (controls). Secondary variables examined were the length and cost of hospital stay. Relevant studies were identified using the PubMed database and by examining the references of the initially selected studies. Two independent reviewers performed the literature search, study selection and data extraction from the identified studies. A total of seven studies were included in the review. The patients included those hospitalized in intensive care units (ICU) and hospital wards and those undergoing transplantation. The mortality attributed to candidemia in the reviewed studies ranged from 5 to 71%. For six of the reviewed studies the difference in mortality between cases and controls was statistically significant. Among those who survived, the length of stay and the cost of hospitalization of patients with candidemia were significantly higher than those of controls. Despite the methodological heterogeneity of the reviewed studies, the data from the available matched cohort and case-control studies suggest that candidemia is associated with considerable mortality that is attributed, at least to some degree, to the infection itself and not only to the presence of another comorbidity.
进行了一项对匹配队列研究和病例对照研究的系统评价，以检查念珠菌血症所致的死亡率。该评价纳入了将念珠菌血症患者（病例）的死亡率与匹配的无念珠菌血症患者（对照）的死亡率进行比较的研究。所检查的次要变量为住院时间和费用。通过PubMed数据库并查阅最初选定研究的参考文献来确定相关研究。两名独立的评审人员进行文献检索、研究选择以及从所确定的研究中提取数据。该评价共纳入七项研究。患者包括入住重症监护病房（ICU）和医院病房的患者以及接受移植的患者。在所审查的研究中，念珠菌血症所致的死亡率在5%至71%之间。在六项审查研究中，病例与对照之间的死亡率差异具有统计学意义。在存活者中，念珠菌血症患者的住院时间和住院费用显著高于对照。尽管所审查的研究在方法上存在异质性，但现有匹配队列研究和病例对照研究的数据表明，念珠菌血症与相当高的死亡率相关，至少在一定程度上可归因于感染本身，而不仅仅是由于存在其他合并症。
