病灶内注射博来霉素与16.5%水杨酸和16.5%乳酸联合涂抹剂治疗跖疣的比较。
Comparison of intralesional bleomycin versus salicylic acid 16.5% and lactic acid 16.5% combination paint in management of plantar warts.
作者信息
Bala Nishu, Kumar Ajay, Ranjan Eeshaan, Gera Vinay, Thombre Rahul
机构信息
Assistant Professor (Dermatology), Command Hospital (Southern Command), Pune, India.
Assistant Professor (Medicine), Command Hospital (Southern Command), Pune, India.
出版信息
Med J Armed Forces India. 2025 May-Jun;81(3):268-274. doi: 10.1016/j.mjafi.2023.04.004. Epub 2023 May 25.
BACKGROUND
Salicylic and lactic acid (SAL) paint is commonly used to treat warts due to ease of application without any instrumentation. Intralesional bleomycin has been used for the treatment of warts since the 1970s with high efficacy even at low concentration. The aim of this study was to assess the efficacy of single dose of intralesional bleomycin in the treatment of plantar warts in comparison with a control group of similar sample receiving SAL paint application.
METHODS
Patients were randomly divided into two groups to receive either single dose of intralesional bleomycin injection or SAL paint application daily for maximum of two months. Plantar warts of the patients were assessed at baseline and with each return visit including a post-treatment follow-up of six months.
RESULTS
Of the 100 patients enrolled in the study, 50 (50%) patients were treated with intralesional bleomycin, and 50 (50%) were treated with SAL paint. Out of total 441 treated warts in 100 patients, 198 (44.89%) warts were treated with intralesional bleomycin, and 243 (55.1%) warts were treated with SAL paint. The clearance rates in the context of number of patients and number of warts were 94% (47 out of 50) and 97.97% (194 out of 198) for bleomycin and 36% (18 out of 50) and 27.5% (67 out of 243) for SAL paint, respectively.
CONCLUSION
Single dose of intralesional bleomycin injection is significantly more effective than SAL paint for the treatment of plantar warts.
背景
水杨酸乳酸（SAL）涂剂因无需任何器械即可轻松涂抹，常用于治疗疣。自20世纪70年代以来，病灶内注射博来霉素一直用于治疗疣，即使在低浓度下也具有高效性。本研究的目的是评估单剂量病灶内注射博来霉素与接受SAL涂剂治疗的相似样本对照组相比，在治疗跖疣方面的疗效。
方法
患者被随机分为两组，分别接受单剂量病灶内注射博来霉素或每日涂抹SAL涂剂，最长持续两个月。在基线时以及每次复诊时对患者的跖疣进行评估，包括治疗后六个月的随访。
结果
在纳入研究的100例患者中，50例（50%）接受病灶内注射博来霉素治疗，50例（50%）接受SAL涂剂治疗。在100例患者的441个接受治疗的疣中，198个（44.89%）疣接受病灶内注射博来霉素治疗，243个（55.1%）疣接受SAL涂剂治疗。就患者数量和疣数量而言，博来霉素的清除率分别为94%（50例中的47例）和97.97%（198例中的194例），SAL涂剂的清除率分别为36%（50例中的18例）和27.5%（243例中的67例）。
结论
单剂量病灶内注射博来霉素治疗跖疣明显比SAL涂剂更有效。
Zotero 插件