中国分离的新型柯萨奇病毒 B5 株全基因组序列。
Full genome sequence of a novel coxsackievirus B5 strain isolated from neurological hand, foot, and mouth disease patients in China.
机构信息
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
J Virol. 2012 Oct;86(20):11408-9. doi: 10.1128/JVI.01709-12.
Abstract
Coxsackievirus B5 (CVB5) belongs to the human enterovirus B species within the family Picornaviridae. We report the complete genome sequence of a novel CVB5 strain, CVB5/SD/09, that is associated with neurological hand, foot, and mouth disease in China. The complete genome consists of 7,399 nucleotides, excluding the 3' poly(A) tail, and has an open reading frame that maps between nucleotide positions 744 and 7301 and encodes a 2,185-amino-acid polyprotein. Phylogenetic analysis based on different genome region regions reveals that CVB5/SD/09 belongs to a novel CVB5 lineage, and similarity plotting and bootscanning analysis based on the whole genome of CVB5 in the present study and those available in GenBank indicate that the genome of CVB5/SD/09 has a mosaic-like structure, suggesting that recombination between different CVB5 strains may occur.
摘要
柯萨奇病毒 B5（CVB5）属于小核糖核酸病毒科肠道病毒 B 属。我们报告了一种新型 CVB5 株 CVB5/SD/09 的完整基因组序列，该病毒与中国的神经手足口病有关。完整基因组由 7399 个核苷酸组成，不包括 3'poly(A) 尾，具有一个开放阅读框，位于核苷酸位置 744 和 7301 之间，编码一个 2185 个氨基酸的多蛋白。基于不同基因组区域的系统进化分析表明，CVB5/SD/09 属于一种新型 CVB5 谱系，而本研究基于 CVB5 全基因组的相似性绘图和引导扫描分析以及 GenBank 中提供的分析表明，CVB5/SD/09 的基因组具有镶嵌样结构，表明不同 CVB5 株之间可能发生重组。
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