鼠白血病病毒中高频率的基因重组：对影响原病毒多倍性的意义。
High rate of genetic recombination in murine leukemia virus: implications for influencing proviral ploidy.
作者信息
Zhuang Jianling, Mukherjee Sayandip, Ron Yacov, Dougherty Joseph P
机构信息
Department of Molecular Genetics, Microbiology and Immunology, UMDNJ/Robert W. Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854-5635, USA.
出版信息
J Virol. 2006 Jul;80(13):6706-11. doi: 10.1128/JVI.00273-06.
Abstract
A significant difference in the recombination rates between human immunodeficiency virus type 1 (HIV-1) and the gammaretroviruses was previously reported, with the former being 10 to 100 times more recombinogenic. It is possible that preferential copackaging of homodimers in the case of gammaretroviruses, like murine leukemia virus (MLV), led to the underestimation of their rates of recombination. To reexamine the recombination rates for MLV, experiments were performed to control for nonrandom copackaging of viral RNA, and it was found that MLV and HIV-1 exhibit similar crossover rates. The implications for control of proviral ploidy and preferential recombination during minus-strand DNA synthesis are discussed.
摘要
先前有报道称，1型人类免疫缺陷病毒（HIV-1）与γ逆转录病毒之间的重组率存在显著差异，前者的重组活性要高10至100倍。对于γ逆转录病毒，如鼠白血病病毒（MLV），同型二聚体的优先共包装可能导致其重组率被低估。为了重新检测MLV的重组率，进行了相关实验以控制病毒RNA的非随机共包装，结果发现MLV和HIV-1表现出相似的交叉率。本文还讨论了负链DNA合成过程中前病毒倍性控制和优先重组的意义。
相似文献
1
High rate of genetic recombination in murine leukemia virus: implications for influencing proviral ploidy.鼠白血病病毒中高频率的基因重组：对影响原病毒多倍性的意义。
J Virol. 2006 Jul;80(13):6706-11. doi: 10.1128/JVI.00273-06.
2
Human immunodeficiency virus type 1 genetic recombination is more frequent than that of Moloney murine leukemia virus despite similar template switching rates.尽管模板转换率相似，但1型人类免疫缺陷病毒的基因重组比莫洛尼鼠白血病病毒更频繁。
J Virol. 2003 Apr;77(8):4577-87. doi: 10.1128/jvi.77.8.4577-4587.2003.
3
Nonrandom dimerization of murine leukemia virus genomic RNAs.鼠白血病病毒基因组RNA的非随机二聚化
J Virol. 2004 Nov;78(22):12129-39. doi: 10.1128/JVI.78.22.12129-12139.2004.
4
Evidence for preferential copackaging of Moloney murine leukemia virus genomic RNAs transcribed in the same chromosomal site.莫洛尼鼠白血病病毒基因组RNA在同一染色体位点转录时优先共包装的证据。
Retrovirology. 2005 Jan 18;2:3. doi: 10.1186/1742-4690-2-3.
5
Transcriptional Silencing of Moloney Murine Leukemia Virus in Human Embryonic Carcinoma Cells.莫洛尼鼠白血病病毒在人胚胎癌细胞中的转录沉默
J Virol. 2016 Dec 16;91(1). doi: 10.1128/JVI.02075-16. Print 2017 Jan 1.
6
Models of HIV type 1 proviral gene expression in wild-type HIV and MLV/HIV transgenic mice.
AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1103-16. doi: 10.1089/aid.1996.12.1103.
7
The virion-associated Gag-Pol is decreased in chimeric Moloney murine leukemia viruses in which the readthrough region is replaced by the frameshift region of the human immunodeficiency virus type 1.在嵌合莫洛尼鼠白血病病毒中，病毒体相关的Gag-Pol减少，其中通读区域被人类免疫缺陷病毒1型的移码区域所取代。
Virology. 2005 Apr 10;334(2):342-52. doi: 10.1016/j.virol.2005.01.044.
8
Effects of identity minimization on Moloney murine leukemia virus template recognition and frequent tertiary template-directed insertions during nonhomologous recombination.身份最小化对莫洛尼鼠白血病病毒模板识别以及非同源重组过程中频繁的三级模板导向插入的影响。
J Virol. 2007 Nov;81(22):12156-68. doi: 10.1128/JVI.01591-07. Epub 2007 Sep 5.
9
Composition and sequence-dependent binding of RNA to the nucleocapsid protein of Moloney murine leukemia virus.RNA与莫洛尼鼠白血病病毒核衣壳蛋白的组成及序列依赖性结合
Biochemistry. 2005 Mar 15;44(10):3735-44. doi: 10.1021/bi047639q.
10
Identification of a high affinity nucleocapsid protein binding element within the Moloney murine leukemia virus Psi-RNA packaging signal: implications for genome recognition.莫洛尼鼠白血病病毒ψ-RNA包装信号内高亲和力核衣壳蛋白结合元件的鉴定：对基因组识别的意义
J Mol Biol. 2001 Nov 23;314(2):217-32. doi: 10.1006/jmbi.2001.5139.
引用本文的文献
1
Deep mutational scanning of proteins in mammalian cells.哺乳动物细胞中蛋白质的深度突变扫描。
Cell Rep Methods. 2023 Nov 20;3(11):100641. doi: 10.1016/j.crmeth.2023.100641. Epub 2023 Nov 13.
2
Recombinant Origins of Pathogenic and Nonpathogenic Mouse Gammaretroviruses with Polytropic Host Range.具有多嗜性宿主范围的致病性和非致病性小鼠γ逆转录病毒的重组起源
J Virol. 2017 Oct 13;91(21). doi: 10.1128/JVI.00855-17. Print 2017 Nov 1.
3
Latent HIV-1 can be reactivated by cellular superinfection in a Tat-dependent manner, which can lead to the emergence of multidrug-resistant recombinant viruses.潜伏的 HIV-1 可以通过 Tat 依赖的细胞再感染而被激活，这可能导致出现多种耐药重组病毒。
J Virol. 2013 Sep;87(17):9620-32. doi: 10.1128/JVI.01165-13. Epub 2013 Jun 26.
4
Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome.免疫逃逸突变对同源传播/原始基因组中 HIV-1 适应性的影响。
Retrovirology. 2012 Oct 30;9:89. doi: 10.1186/1742-4690-9-89.
5
Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples.内源性鼠白血病病毒：与在人类DNA样本中检测到的XMRV及相关序列的关系
Adv Virol. 2011;2011:940210. doi: 10.1155/2011/940210. Epub 2011 Oct 24.
6
XMRV and prostate cancer--a 'final' perspective.XMRV 与前列腺癌——一个“最终”的视角。
Nat Rev Urol. 2012 Jan 10;9(2):111-8. doi: 10.1038/nrurol.2011.225.
7
Mechanisms and factors that influence high frequency retroviral recombination.影响高频逆转录病毒重组的机制和因素。
Viruses. 2011 Sep;3(9):1650-1680. doi: 10.3390/v3091650. Epub 2011 Sep 9.
8
Origin of XMRV and its demise as a human pathogen associated with chronic fatigue syndrome.XMRV 的起源及其作为与慢性疲劳综合征相关的人类病原体的消亡。
Viruses. 2011 Aug;3(8):1312-9. doi: 10.3390/v3081312. Epub 2011 Jul 27.
9
Recombinant origin of the retrovirus XMRV.逆转录病毒 XMRV 的重组起源。
Science. 2011 Jul 1;333(6038):97-101. doi: 10.1126/science.1205292. Epub 2011 May 31.
10
Retroviral RNA dimerization and packaging: the what, how, when, where, and why.逆转录病毒RNA二聚化与包装：是什么、如何、何时、何地以及为何。
PLoS Pathog. 2010 Oct 7;6(10):e1001007. doi: 10.1371/journal.ppat.1001007.
本文引用的文献
1
Retroviral superinfection resistance.逆转录病毒双重感染抗性
Retrovirology. 2005 Aug 18;2:52. doi: 10.1186/1742-4690-2-52.
2
Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription.抑制人类免疫缺陷病毒转录的染色体特征的全基因组分析。
J Virol. 2005 Jun;79(11):6610-9. doi: 10.1128/JVI.79.11.6610-6619.2005.
3
Evidence for preferential copackaging of Moloney murine leukemia virus genomic RNAs transcribed in the same chromosomal site.莫洛尼鼠白血病病毒基因组RNA在同一染色体位点转录时优先共包装的证据。
Retrovirology. 2005 Jan 18;2:3. doi: 10.1186/1742-4690-2-3.
4
Nonrandom dimerization of murine leukemia virus genomic RNAs.鼠白血病病毒基因组RNA的非随机二聚化
J Virol. 2004 Nov;78(22):12129-39. doi: 10.1128/JVI.78.22.12129-12139.2004.
5
Frequent dual initiation in human immunodeficiency virus-based vectors containing two primer-binding sites: a quantitative in vivo assay for function of initiation complexes.在含有两个引物结合位点的基于人类免疫缺陷病毒的载体中频繁的双重起始：起始复合物功能的定量体内测定。
J Virol. 2004 May;78(10):5402-13. doi: 10.1128/jvi.78.10.5402-5413.2004.
6
Dynamics of HIV-1 recombination in its natural target cells.HIV-1在其自然靶细胞中的重组动力学。
Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4204-9. doi: 10.1073/pnas.0306764101. Epub 2004 Mar 9.
7
Frequent dual initiation of reverse transcription in murine leukemia virus-based vectors containing two primer-binding sites.在含有两个引物结合位点的基于鼠白血病病毒的载体中频繁发生逆转录的双重起始。
Virology. 2003 Aug 1;312(2):281-94. doi: 10.1016/s0042-6822(03)00300-3.
8
Human immunodeficiency virus type 1 genetic recombination is more frequent than that of Moloney murine leukemia virus despite similar template switching rates.尽管模板转换率相似，但1型人类免疫缺陷病毒的基因重组比莫洛尼鼠白血病病毒更频繁。
J Virol. 2003 Apr;77(8):4577-87. doi: 10.1128/jvi.77.8.4577-4587.2003.
9
Human immunodeficiency virus type 1 recombination: rate, fidelity, and putative hot spots.1型人类免疫缺陷病毒重组：频率、保真度及假定热点
J Virol. 2002 Nov;76(22):11273-82. doi: 10.1128/jvi.76.22.11273-11282.2002.
10
HIV-1 sequence variation: drift, shift, and attenuation.HIV-1序列变异：漂移、转变与衰减。
Cell. 2001 Feb 23;104(4):469-72. doi: 10.1016/s0092-8674(01)00234-3.
Zotero 插件