卡波韦尔：其左旋对映体在体外是一种针对人类免疫缺陷病毒的强效且选择性抗病毒剂。
Carbovir: the (-) enantiomer is a potent and selective antiviral agent against human immunodeficiency virus in vitro.
作者信息
Coates J A, Inggall H J, Pearson B A, Penn C R, Storer R, Williamson C, Cameron J M
机构信息
Department of Virology, Glaxo Group Research Limited, Greenford, U.K.
出版信息
Antiviral Res. 1991 Feb;15(2):161-8. doi: 10.1016/0166-3542(91)90033-n.
In this paper we describe the in vitro antiviral activity of the (-) enantiomer of carbocyclic 2',3'-deoxydidehydroguanosine, (-) carbovir, a nucleoside analogue that has selective and potent anti-HIV activity in a series of lymphocyte culture systems. The cellular cytotoxicity of this compound has also been evaluated in a number of systems and compared to the saturated dideoxynucleoside analogues AZT and ddC.
在本文中，我们描述了碳环2'，3'-二脱氧脱氢鸟苷的（-）对映体（-）卡波韦的体外抗病毒活性，卡波韦是一种核苷类似物，在一系列淋巴细胞培养系统中具有选择性和强效的抗HIV活性。还在多个系统中评估了该化合物的细胞毒性，并与饱和双脱氧核苷类似物齐多夫定和双脱氧胞苷进行了比较。
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