Coates J A, Inggall H J, Pearson B A, Penn C R, Storer R, Williamson C, Cameron J M
Department of Virology, Glaxo Group Research Limited, Greenford, U.K.
Antiviral Res. 1991 Feb;15(2):161-8. doi: 10.1016/0166-3542(91)90033-n.
In this paper we describe the in vitro antiviral activity of the (-) enantiomer of carbocyclic 2',3'-deoxydidehydroguanosine, (-) carbovir, a nucleoside analogue that has selective and potent anti-HIV activity in a series of lymphocyte culture systems. The cellular cytotoxicity of this compound has also been evaluated in a number of systems and compared to the saturated dideoxynucleoside analogues AZT and ddC.
在本文中，我们描述了碳环2'，3'-二脱氧脱氢鸟苷的（-）对映体（-）卡波韦的体外抗病毒活性，卡波韦是一种核苷类似物，在一系列淋巴细胞培养系统中具有选择性和强效的抗HIV活性。还在多个系统中评估了该化合物的细胞毒性，并与饱和双脱氧核苷类似物齐多夫定和双脱氧胞苷进行了比较。
