Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1.
作者信息
Smith M S, Kessler J A, Rankin C D, Pagano J S, Kurtzberg J, Carter S G
机构信息
Lineberger Comprehensive Cancer Research Center, University of North Carolina, Chapel Hill 27599-7295.
出版信息
Antimicrob Agents Chemother. 1993 Jan;37(1):144-7. doi: 10.1128/AAC.37.1.144.
Abstract
3'-Azido-2',3'-deoxythymidine and carbovir [racemic and (-) enantiomer] were evaluated individually and in combination for antiviral activity against human immunodeficiency virus type 1 replication and cytotoxicity in vitro. The combination of these drugs synergistically inhibited human immunodeficiency virus type 1 replication in C3 and Jurkat cells and in human peripheral blood mononuclear cells, although the same combination also produced synergistic cytotoxicity in human peripheral blood mononuclear cells.
摘要
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