卡波韦和3'-叠氮-2',3'-双脱氧胸苷协同抑制1型人类免疫缺陷病毒的评估。
Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1.
作者信息
Smith M S, Kessler J A, Rankin C D, Pagano J S, Kurtzberg J, Carter S G
机构信息
Lineberger Comprehensive Cancer Research Center, University of North Carolina, Chapel Hill 27599-7295.
出版信息
Antimicrob Agents Chemother. 1993 Jan;37(1):144-7. doi: 10.1128/AAC.37.1.144.
Abstract
3'-Azido-2',3'-deoxythymidine and carbovir [racemic and (-) enantiomer] were evaluated individually and in combination for antiviral activity against human immunodeficiency virus type 1 replication and cytotoxicity in vitro. The combination of these drugs synergistically inhibited human immunodeficiency virus type 1 replication in C3 and Jurkat cells and in human peripheral blood mononuclear cells, although the same combination also produced synergistic cytotoxicity in human peripheral blood mononuclear cells.
摘要
对3'-叠氮基-2',3'-脱氧胸苷和卡波韦（消旋体和(-)对映体）分别及联合进行了评估，以检测其对1型人类免疫缺陷病毒复制的体外抗病毒活性和细胞毒性。这些药物的联合在C3细胞、Jurkat细胞及人外周血单个核细胞中协同抑制1型人类免疫缺陷病毒的复制，尽管相同的联合在人外周血单个核细胞中也产生了协同细胞毒性。
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