McGuire Deborah B, Correa Maria Elvira P, Johnson Judith, Wienandts Patricia
School of Nursing, University of Maryland, Baltimore, 655 West Lombard Street, Baltimore, 21201, USA.
Support Care Cancer. 2006 Jun;14(6):541-7. doi: 10.1007/s00520-006-0051-8. Epub 2006 Apr 25.
The Basic Oral Care Group is one of eight subcommittees functioning within the Mucositis Study Group Guidelines Panel of the Multinational Association of Supportive Care in Cancer and International Society for Oral Oncology (MASCC/ISOO). The Basic Oral Care Group, comprised of the four authors of this paper, represented the disciplines of nursing (DBM, JJ), dentistry (MEPC), and pediatric dentistry (PW). This group reviewed research and clinical literature to update the original 2004 Mucositis Management Guidelines in the areas of basic oral care, bland rinses, protocols and education, and good clinical practices such as pain management, oral assessment, oral care, and dental care.
Over 100 articles published between 2000 and 2005 were identified, and 32 of these were useful for the analysis. Each article was rated by at least two authors using a structured rating form and systematic determination of levels of evidence, based on the American Society of Clinical Oncology criteria. Discussion at the 2005 MASCC/ISOO Geneva pre-conference meeting of the Guidelines Panel resulted in the development of consensus on the interpretation of the literature.
Based on the literature and on Panel discussions, a revision of the original guidelines for protocols and education was produced by the group, and they developed a set of recommendations related to good clinical practices.
Although research remains scanty for components of basic oral care, bland rinses, protocols, and education, the original 2004 guidelines with the help of newer literature from 2000 to 2005 and expert consensus among the Guidelines Panel enabled the development of useful clinical practice guidelines for managing oral mucositis in patients receiving cancer treatment with radiation and/or chemotherapy.
基础口腔护理小组是癌症支持治疗多国协会和国际口腔肿瘤学会（MASCC/ISOO）粘膜炎研究组指南小组下属的八个小组委员会之一。该基础口腔护理小组由本文的四位作者组成，代表了护理（DBM、JJ）、牙科（MEPC）和儿童牙科（PW）等学科。该小组回顾了研究和临床文献，以更新2004年原始粘膜炎管理指南中基础口腔护理、温和漱口、方案与教育以及疼痛管理、口腔评估、口腔护理和牙科护理等良好临床实践方面的内容。
确定了2000年至2005年间发表的100多篇文章，其中32篇对分析有用。每篇文章至少由两位作者使用结构化评分表并根据美国临床肿瘤学会标准系统确定证据水平进行评分。指南小组在2005年MASCC/ISOO日内瓦会前会议上进行的讨论促成了对文献解读的共识。
基于文献和小组讨论，该小组对原始的方案与教育指南进行了修订，并制定了一套与良好临床实践相关的建议。
尽管基础口腔护理、温和漱口、方案和教育等方面的研究仍然匮乏，但借助2000年至2005年的最新文献以及指南小组的专家共识，2004年的原始指南得以制定出有用的临床实践指南，用于管理接受放疗和/或化疗的癌症患者的口腔粘膜炎。
