Kraft B, Leroy S, Schweizer M, Junginger W, Bittner R
Abteilung für Allgemein- und Visceralchirurgie, Marienhospital, Böheimstrasse 37, 70199 Stuttgart.
Chirurg. 2006 Oct;77(10):913-8. doi: 10.1007/s00104-006-1202-7.
The goal of our study was to evaluate the morphine-sparing effect of nonsteroidal anti-inflammatory drugs (NSAIDs) following both conventional and laparoscopic colon surgery.
In this prospective, randomized clinical trial, 180 patients were assigned to three groups. Two groups received either paracetamol or parecoxib/valdecoxib in addition to piritramid via patient-controlled or nurse-controlled analgesia pump. Patients in the control group received piritramid only. The total piritramid consumption during hospital stay was recorded.
Total opioid consumption was significantly lower in the two groups who received NSAIDs. Comparing conventional and laparoscopic surgery, the latter group had much lower opioid consumption.
The use of NSAIDs following colon surgery significantly reduces postoperative opioid consumption.
我们研究的目的是评估非甾体抗炎药（NSAIDs）在传统和腹腔镜结肠手术后的吗啡节省效应。
在这项前瞻性随机临床试验中，180例患者被分为三组。两组除了通过患者自控或护士控制镇痛泵给予匹米诺定外，还分别接受对乙酰氨基酚或帕瑞昔布/伐地昔布。对照组患者仅接受匹米诺定。记录住院期间匹米诺定的总消耗量。
接受NSAIDs的两组患者的阿片类药物总消耗量显著更低。比较传统手术和腹腔镜手术，后一组的阿片类药物消耗量要低得多。
结肠手术后使用NSAIDs可显著降低术后阿片类药物的消耗量。
