Lal R B, Rudolph D L
Retrovirus Diseases Branch, Centers for Disease Control, Atlanta, GA 30333.
Blood. 1991 Aug 1;78(3):571-4.
The human T-cell lymphotropic viruses (HTLV) type I and type II are capable of inducing a variety of cellular genes, including many of the cytokines that regulate cell proliferation. To determine if the spontaneous proliferation of peripheral blood mononuclear cells from patients infected with HTLV-I and HTLV-II was related to coordinate expression of cytokines, we analyzed the levels of interleukin-1 beta (IL-1 beta), IL-2, IL-3, IL-4, IL-6, tumor necrosis factor-alpha (TNF-alpha) and interferon-tau (IFN-tau) in culture supernatants derived from spontaneously proliferating cells. Significantly elevated levels of IL-6 and TNF-alpha were present in culture supernatants from HTLV-I/II-infected individuals when compared with normal controls (P less than .01). Kinetic experiments showed that both IL-6 and TNF-alpha were elevated by day 5. None of the other cytokines (IL-1 beta, IL-2, IL-3, IL-4, and IFN-tau) were detectable in any of the culture. These data suggest that release of IL-6 and TNF-alpha may regulate lymphocyte proliferation in HTLV-I/II-infected individuals.
I型和II型人类嗜T细胞病毒（HTLV）能够诱导多种细胞基因，包括许多调节细胞增殖的细胞因子。为了确定感染HTLV-I和HTLV-II患者外周血单个核细胞的自发增殖是否与细胞因子的协同表达有关，我们分析了来自自发增殖细胞的培养上清液中白细胞介素-1β（IL-1β）、IL-2、IL-3、IL-4、IL-6、肿瘤坏死因子-α（TNF-α）和干扰素-τ（IFN-τ）的水平。与正常对照相比，HTLV-I/II感染个体的培养上清液中IL-6和TNF-α水平显著升高（P<0.01）。动力学实验表明，到第5天时IL-6和TNF-α均升高。在任何培养物中均未检测到其他细胞因子（IL-1β、IL-2、IL-3、IL-4和IFN-τ）。这些数据表明，IL-6和TNF-α的释放可能调节HTLV-I/II感染个体中的淋巴细胞增殖。
