Aybey Bekir, Coşkun Diler, Aytaç Jale
Florence Nightingale Hastanesi, Dermatoloji Kliniği, Cağlayan, Istanbul.
Mikrobiyol Bul. 2006 Jan-Apr;40(1-2):103-7.
In this report, a case of transfusion-associated graft versus host disease that developed following coronary arter bypass grafting and mitral annuloplasty operations, has been presented. The diagnosis of 62 year-old male patient was based on the presence of typical findings as fever, liver function disorders, skin rash and hypoplastic bone marrow findings that began ten days after the operation; with the exclusion of other pathologies (e.g. drug eruptions, viral infections, septicemia, scalded skin syndrome and toxic epidermal necrolysis) and histopathological findings of skin biopsy. There was a history of five units of blood transfusion of which one was from a close relative. The blood from the relative was thought to be responsible for the disease. With this case, we wanted to emphasize once more that transfusion of the blood of a relative must be avoided in patients who have undergone major operations such as cardiovascular surgery. The irradiation of these bloods before transfusion may be effective to prevent graft versus host disease.
在本报告中，介绍了一例在冠状动脉搭桥术和二尖瓣环成形术后发生的输血相关移植物抗宿主病病例。一名62岁男性患者的诊断基于术后十天出现的典型症状，如发热、肝功能紊乱、皮疹和骨髓发育不全的表现；排除了其他病理情况（如药物疹、病毒感染、败血症、烫伤样皮肤综合征和中毒性表皮坏死松解症）以及皮肤活检的组织病理学结果。患者有过五次输血史，其中一次来自近亲。据认为来自该亲属的血液是导致该病的原因。通过这个病例，我们想再次强调，对于接受过心血管手术等大手术的患者，必须避免输注亲属的血液。在输血前对这些血液进行辐照可能有效预防移植物抗宿主病。
