Souma T, Tsuchida S, Otani S, Kojima M, Tsunoda R
Nihon Kyobu Geka Gakkai Zasshi. 1989 Jun;37(6):1257-61.
An immunologically normal 70-year-old male developed fever and disturbance of consciousness after aortocoronary bypass; this was followed by diarrhea, systemic erythroderma and granulocytopenia. He died as a result of sepsis and acute renal failure. The skin biopsy showed basel vacuolar degeneration, epidermal eosinophilic necrosis and invasion of T-lymphocytes. The autopsy showed necrotic small interlobular bile ducts, severely hypoplastic bone marrow and widespread necrosis of lymphoid tissue. Based on these clinicopathological findings, we made a diagnosis of graft-versus host reaction after transfusion.
一名70岁免疫功能正常的男性在接受主动脉冠状动脉搭桥手术后出现发热和意识障碍；随后出现腹泻、全身性红皮病和粒细胞减少。他因败血症和急性肾衰竭死亡。皮肤活检显示基底细胞空泡变性、表皮嗜酸性坏死和T淋巴细胞浸润。尸检显示小叶间胆管坏死、骨髓严重发育不全和淋巴组织广泛坏死。基于这些临床病理表现，我们诊断为输血后移植物抗宿主反应。
