Bruno Ivone, Wilkinson Miles F
Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA.
Cell. 2006 Jun 16;125(6):1036-8. doi: 10.1016/j.cell.2006.06.003.
P-bodies are specialized cytoplasmic compartments where translational repression and mRNA turnover may occur. Findings in this issue of Cell provide evidence that P-bodies are sites of "mRNA purgatory." Bhattacharyya et al. (2006) reveal that normal mRNA can be released from P-bodies and translated into protein in response to stress. Meanwhile, Sheth and Parker (2006) report that aberrant mRNAs are targeted to P-bodies to undergo rapid decay.
P小体是特殊的细胞质区室，在其中可能发生翻译抑制和mRNA周转。本期《细胞》杂志上的研究结果提供了证据，表明P小体是“mRNA炼狱”的场所。巴塔查里亚等人（2006年）揭示，正常mRNA可以从P小体中释放出来，并在应激反应时被翻译成蛋白质。与此同时，谢思和帕克（2006年）报告称，异常mRNA会被靶向输送到P小体，从而迅速降解。
