Zamarrón Carlos, Abdulkader Ihab, Alvarez Uxio Calvo, Barón Franciisco Javiver, Prim Jose Maria Garcia, Ledo Ramiro Ledo Andio, Forteza Jeronimo
Division of Respiratory Medicine, Hospital Clínico Universitario, Santiago, Spain.
Intern Med. 2006;45(10):679-83. doi: 10.2169/internalmedicine.45.1508. Epub 2006 Jun 15.
A 45 -year-old woman presented chest pain and a well-defined oval shaped mass on a chest radiograph. A malignant pulmonary tumor was suspected and a right pneumonectomy was performed. The tumor measured about 13 x 12 cm, was pale-yellow in color and soft in texture. Histologically, it had round to oval and spindle-shaped cells with minimal cytoplasm, hyperchromatic nuclei, inconspicuous mitoses and only slight fibrous stroma. Immunohistochemically, the tumor cells were positive for vimentin, CD 99, BCL-2 protein and EMA. The reverse transcriptase-polymerase chain reaction (RT-PCR), using RNA extracted from fresh-frozen tissue, demonstrated SYT/SSX-2 fusion transcripts, confirming the diagnosis of synovial sarcoma.
一名45岁女性出现胸痛，胸部X线片显示有一个边界清晰的椭圆形肿块。怀疑为恶性肺肿瘤，遂行右肺切除术。肿瘤大小约为13×12 cm，呈淡黄色，质地柔软。组织学上，肿瘤细胞呈圆形至椭圆形及梭形，胞质极少，核深染，核分裂不明显，纤维间质轻微。免疫组织化学检查显示，肿瘤细胞波形蛋白、CD 99、BCL-2蛋白及上皮膜抗原（EMA）呈阳性。利用从新鲜冷冻组织中提取的RNA进行逆转录聚合酶链反应（RT-PCR），证实存在SYT/SSX-2融合转录本，确诊为滑膜肉瘤。
