Hall Gillian, Duncan Alison, Azurdia Richard, Leonard Niamh
Department of Pathology, Royal Liverpool and Broad Green University Hospital Trust, Liverpool, England.
Am J Dermatopathol. 2006 Jun;28(3):211-5. doi: 10.1097/00000372-200606000-00007.
We report a case of a primary lymphoepithelioma-like carcinoma (LELC) of the skin. The patient was a 73-year-old man with a lump on his back for 18 months. A biopsy and subsequent excision was performed. He also had axillary node clearance for metastatic disease. The tumor was composed of islands of pleomorphic cells with a lymphocytic infiltrate. Differential diagnoses included squamous cell carcinoma, adnexal carcinoma, Merkel cell tumors, lymphoepithelial lesions, lymphomas, and skin metastases. The histopathologic and immunohistochemical features were those of a LELC of the skin. It was negative for Epstein-Barr virus. Just over 30 cases of primary LELCs arising in the skin have been reported with only 1 documented fatality. We report a case with extensive vascular involvement and bilateral lymph node metastases.
我们报告一例原发性皮肤淋巴上皮瘤样癌（LELC）。患者为一名73岁男性，背部肿物18个月。进行了活检及后续切除。因转移性疾病还进行了腋窝淋巴结清扫。肿瘤由多形性细胞岛及淋巴细胞浸润组成。鉴别诊断包括鳞状细胞癌、附属器癌、默克尔细胞瘤、淋巴上皮病变、淋巴瘤及皮肤转移瘤。组织病理学和免疫组化特征符合皮肤LELC。爱泼斯坦-巴尔病毒检测为阴性。据报道，原发性皮肤LELC病例刚超过30例，仅1例有死亡记录。我们报告一例有广泛血管受累及双侧淋巴结转移的病例。
