生化物种差异对有机化学品鱼类急性毒性的影响。

The influence of biochemical species differences on acute fish toxicity of organic chemicals.

Sijm D T, Flenner C K, Opperhuizen A

Research Institute of Toxicology, University of Utrecht, The Netherlands.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;100(1-2):33-5. doi: 10.1016/0742-8413(91)90117-c.

Abstract

Reported LC50s of hundreds of chemicals and data of many enzymes in many fishes have been reviewed in order to find the hypothesized influence of biotransformation on acute toxicity. 2. Biotransformation of carbaryl was correlated and biotransformation of endrin was inversely correlated with acute toxicity. 3. For most compounds no correlation was found which indicates that either biotransformation is not important in acute toxicity or enzyme activities are not representative parameters to quantify biotransformation reactions.

摘要

为了探寻生物转化对急性毒性的假定影响，已对数百种化学物质的报告半数致死浓度（LC50）以及许多鱼类中多种酶的数据进行了综述。2. 西维因的生物转化与急性毒性呈正相关，而异狄氏剂的生物转化与急性毒性呈负相关。3. 对于大多数化合物，未发现相关性，这表明要么生物转化在急性毒性中不重要，要么酶活性不是量化生物转化反应的代表性参数。