Coulie P J, Ghys L, Rihoux J P
UCB Pharmaceutical Sector, Braine-l'Alleud, Belgium.
J Int Med Res. 1991 Mar-Apr;19(2):174-9. doi: 10.1177/030006059101900213.
In an open, randomized crossover study, the inhibition of histamine-induced weals and flares after one dose of 10 mg cetirizine administered orally or sublingually to seven healthy volunteers was compared. Formation of both weals and flares was significantly inhibited by cetirizine administered by either route; weals were inhibited as early as 20 min after oral intake but not clearly inhibited until 90 min after sublingual intake. There was no clinically relevant difference between the effects of the two routes of administration on flare area. Cetirizine was not well tolerated when given sublingually: two patients reported a burning sensation in the tongue and one reported a local anaesthetic effect. Plasma cetirizine concentrations showed no clear difference between the two routes of administration.
在一项开放性随机交叉研究中，比较了对7名健康志愿者口服或舌下给予10毫克西替利嗪一剂后，对组胺诱导的风团和潮红的抑制作用。两种给药途径给予的西替利嗪均能显著抑制风团和潮红的形成；口服后20分钟风团即受到抑制，但舌下给药后直到90分钟才受到明显抑制。两种给药途径对潮红面积的影响在临床上无显著差异。舌下给药时西替利嗪的耐受性不佳：两名患者报告舌头有烧灼感，一名患者报告有局部麻醉作用。两种给药途径的血浆西替利嗪浓度无明显差异。
