Pechadre J C, Beudin P, Eschalier A, Trolese J F, Rihoux J P
Electro-encephalography Laboratory, Hôtel Dieu, Clermont, Ferrand, France.
J Int Med Res. 1991 Jul-Aug;19(4):289-95. doi: 10.1177/030006059101900401.
In a double-blind, crossover, randomized clinical pharmacological study performed on 10 healthy volunteers, peripheral and central effects of 10 mg cetirizine and 10 and 40 mg loratadine were compared. Cetirizine (10 mg) significantly (P less than 0.001) inhibited 10 or 100 mg/ml histamine-induced weals 2 and 6 h after drug intake. Cetirizine was more potent than 10 mg loratadine after 2 and 6 h, and was even more potent than 40 mg loratadine after 6 h. Neither drug affected subjective evaluation of central effects and cetirizine was completely devoid of electro-encephalographic (EEG) changes, whereas 10 and 40 mg loratadine induced only slight and limited EEG changes.
在一项针对10名健康志愿者进行的双盲、交叉、随机临床药理学研究中，比较了10毫克西替利嗪以及10毫克和40毫克氯雷他定的外周和中枢效应。西替利嗪（10毫克）在服药后2小时和6小时显著（P小于0.001）抑制了10或100毫克/毫升组胺诱导的风团。西替利嗪在2小时和6小时后比10毫克氯雷他定更有效，在6小时后甚至比40毫克氯雷他定更有效。两种药物均未影响中枢效应的主观评估，且西替利嗪完全没有脑电图（EEG）变化，而10毫克和40毫克氯雷他定仅引起轻微且有限的脑电图变化。
