Rihoux J P, Ghys L, Coulie P
UCB, SA, Pharmaceutical Sector, Chemin du Foriest, Belgium.
Ann Allergy. 1990 Aug;65(2):139-42.
Histamine-induced wheals and flares were measured in seven healthy volunteers zero, four, and eight hours after oral intake of cetirizine, 2.5, 5, and 10 mg; loratadine, 10, 20, and 40 mg; and placebo. Cetirizine (2.5, 5, and 10 mg) and loratadine (20 and 40 mg) significantly inhibited the histamine-induced wheals at all experimental times and with all histamine concentrations. This was not always the case with loratadine, 10 mg. Cetirizine, 2.5 mg, was as potent in inhibiting the histamine skin reactivity as loratadine, 10 mg.
在七名健康志愿者口服2.5毫克、5毫克和10毫克西替利嗪、10毫克、20毫克和40毫克氯雷他定以及安慰剂后的零小时、四小时和八小时，测量组胺诱发的风团和红晕。西替利嗪（2.5毫克、5毫克和10毫克）和氯雷他定（20毫克和40毫克）在所有实验时间和所有组胺浓度下均显著抑制组胺诱发的风团。10毫克氯雷他定并非总是如此。2.5毫克西替利嗪在抑制组胺皮肤反应性方面与10毫克氯雷他定一样有效。
