英夫利昔单抗治疗后麻风病及1型麻风反应的发生：2例报告
Development of leprosy and type 1 leprosy reactions after treatment with infliximab: a report of 2 cases.
作者信息
Scollard D M, Joyce M P, Gillis T P
机构信息
National Hansen's Disease Programs, Louisiana State University, Baton Rouge, LA 70803, USA.
出版信息
Clin Infect Dis. 2006 Jul 15;43(2):e19-22. doi: 10.1086/505222. Epub 2006 Jun 9.
DOI:10.1086/505222
PMID:16779736
Abstract
Humanized monoclonal antibodies to tumor necrosis factor- alpha are valuable for the treatment of rheumatologic conditions, but they have been associated with the development of serious infections. We report the first 2 cases of leprosy developing after treatment with infliximab. After discontinuation of infliximab, both patients developed type 1 ("reversal") leprosy reactions.
摘要
抗肿瘤坏死因子-α人源化单克隆抗体对治疗风湿性疾病很有价值，但它们与严重感染的发生有关。我们报告了2例在用英夫利昔单抗治疗后发生麻风病的首例病例。停用英夫利昔单抗后，两名患者均出现了1型（“逆转”）麻风反应。
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