Department of Dermatology, Dr. Ram Manohar Lohia Hospital and Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, India.
Department of Pathology, Dr. Ram Manohar Lohia Hospital and Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, India.
Am J Trop Med Hyg. 2022 Jun 6;107(1):94-96. doi: 10.4269/ajtmh.22-0099. Print 2022 Jul 13.
Type 1 lepra reaction (T1R) is a major complication seen in nonpolar forms of leprosy and leads to significant morbidity. The classification of T1R as up and downgrading, based on previously defined histopathological criteria (by Ridley), has therapeutic and prognostic implications. The trigger factors for these reactions are poorly described, especially in case of downgrading T1R and we describe a case of leprosy reaction that was possibly triggered by chemoradiation and elucidate the possible mechanism.
1 型麻风反应（T1R）是麻风的非瘤型中常见的一种严重并发症，可导致严重的发病率。T1R 根据 Ridley 之前定义的组织病理学标准分为升级和降级，具有治疗和预后意义。这些反应的触发因素描述不佳，尤其是降级 T1R 的情况，我们描述了一例可能由化疗和放疗引发的麻风反应，并阐明了可能的机制。
