Matuszewski Vanessa, Piolino Pascale, de la Sayette Vincent, Lalevée Catherine, Pélerin Alice, Dupuy Benoît, Viader Fausto, Eustache Francis, Desgranges Béatrice
Inserm-EPHE-Université de Caen, Unité E0218, GIP Cyceron, CHU de Caen, Caen, France.
Neuropsychologia. 2006;44(12):2386-97. doi: 10.1016/j.neuropsychologia.2006.04.031. Epub 2006 Jun 14.
Very few studies have investigated autobiographical memory in the frontal variant of frontotemporal dementia (fv-FTD). The aim of this study was therefore to unravel the mechanisms of autobiographical memory disruption in general and in the anterograde and retrograde components of amnesia in particular, in patients suffering from fv-FTD. An autobiographical memory task assessing overall (AM) and strictly episodic memories (EM) from five lifetime periods covering the entire lifespan revealed the absence of a temporal gradient for both scores, suggesting the existence of a retrieval deficit. An analysis of the correlation between these two scores and a general cognitive assessment of executive function, working, episodic (i.e. new learning ability) and semantic memory, and behavioural changes highlighted the considerable involvement of executive function, semantic memory and, to a lesser degree, episodic memory and behavioural changes. Moreover, step-wise regression analyses performed on the EM score revealed that the executive function was a better predictor of the retrograde component than of the anterograde component, which was linked principally to new episodic learning ability. All these results confirm the impact of executive dysfunction on autobiographical deficits in fv-FTD, and suggest that the mechanisms at the root of autobiographical memory disruption may also involve difficulties in new episodic learning and semantic storage, though this may be due to the fact that we studied an advanced form of fv-FTD.
极少有研究对额颞叶痴呆的额叶变异型（fv-FTD）患者的自传体记忆进行调查。因此，本研究的目的是揭示fv-FTD患者自传体记忆障碍的机制，特别是失忆症的顺行性和逆行性成分中的自传体记忆障碍机制。一项自传体记忆任务评估了涵盖整个生命周期的五个生命阶段的整体（AM）和严格的情景记忆（EM），结果显示这两个分数均不存在时间梯度，这表明存在检索缺陷。对这两个分数与执行功能、工作记忆、情景记忆（即新学习能力）和语义记忆的一般认知评估以及行为变化之间的相关性分析突出了执行功能、语义记忆以及在较小程度上情景记忆和行为变化的显著参与。此外，对EM分数进行的逐步回归分析表明，执行功能对逆行性成分的预测能力优于顺行性成分，顺行性成分主要与新情景学习能力相关。所有这些结果证实了执行功能障碍对fv-FTD患者自传体记忆缺陷的影响，并表明自传体记忆破坏的根本机制可能还涉及新情景学习和语义存储方面的困难，尽管这可能是由于我们研究的是fv-FTD的晚期形式。
