Gangl M, Serteyn D, Lejeune J-Ph, Schneider N, Grulke S, Peters F, Vila T, Deby-Dupont G, Deberg M, Henrotin Y
Department of Clinical Sciences, Large Animal Surgery, Faculty of Veterinary Medicine, University of Liège, Sart Tilman B41, B-4000 Liège, Belgium.
Res Vet Sci. 2007 Feb;82(1):68-75. doi: 10.1016/j.rvsc.2006.03.008. Epub 2006 Jun 14.
Markers of cartilage breakdown enable studying the degradation of cartilage matrix in equine joint pathologies. This study was designed to determine the levels of Coll2-1, a peptide of the triple helix of type II collagen, and Coll2-1NO(2), its nitrated form in the plasma of healthy horses (controls; n=37) and horses suffering from osteochondrosis (n=34). Clinical and arthroscopic scores were attributed reflecting the severity of lesions and were related to the plasma levels of Coll2-1 and Coll2-1NO(2). The median of Coll2-1 was significantly higher in the control group, whereas the mean of Coll2-1NO(2) showed significant elevation in the pathological group. However, the measurement means of scoring classes did not vary significantly. The markers were able to differentiate the group of horses suffering from osteochondrosis from the group of healthy horses. The elevation of Coll2-1NO(2) in the pathological group indicates an inflammation, mediated through reactive oxygen species and/or increased myeloperoxidase activity.
软骨降解标志物有助于研究马关节疾病中软骨基质的降解情况。本研究旨在测定健康马（对照组；n = 37）和患有骨软骨病的马（n = 34）血浆中II型胶原三螺旋肽Coll2 - 1及其硝化形式Coll2 - 1NO(2)的水平。根据病变严重程度给出临床和关节镜评分，并将其与Coll2 - 1和Coll2 - 1NO(2)的血浆水平相关联。对照组中Coll2 - 1的中位数显著更高，而病理组中Coll2 - 1NO(2)的均值显著升高。然而，各评分等级的测量均值没有显著差异。这些标志物能够区分患有骨软骨病的马群和健康马群。病理组中Coll2 - 1NO(2)的升高表明存在由活性氧和/或髓过氧化物酶活性增加介导的炎症。
