García Heredia M, García S D, Copolillo E F, Cora Eliseth M, Barata A D, Vay C A, de Torres R A, Tiraboschi N, Famiglietti A M R
Carrera de Especialización en Bacteriología, Escuela de Graduados, Facultad de Farmacia y Bioquímica, UBA.
Rev Argent Microbiol. 2006 Jan-Mar;38(1):9-12.
Pregnant women are more susceptible to both vaginal colonization and infection by yeast. Our objectives were to determine the prevalence in pregnant women of yeasts isolated from vaginal exudates and their susceptibility to current antifungal drugs. A total of 493 patients was studied between December 1998 and February 2000. The prevalence of Candida spp. was 28% (Candida albicans 90.4%; Candida glabrata 6.3%; Candida parapsilosis 1.1%, Candida kefyr 1.1 %; unidentified species 1.1 %). The diffusion test in Shadomy agar was employed to determine the susceptibility to fluconazole, ketoconazole, itraconazole and nistatine. All C. albicans, C. kefyr and C. parapsilosis isolates were susceptible in vitro to the antifungal agents tested, while 1 in 6 C. glabrata isolates showed resistance to azole drugs; all strains were susceptible to nistatine. In pregnant women, C. albicans was the yeast most frequently isolated from vaginal exudates; it continues to be highly susceptible to antifungal drugs. Azole resistance was detected only among C. glabrata isolates. Identification to the species level is recommended, specially in cases of treatment failure and recurrent or chronic infection.
孕妇更容易受到酵母菌的阴道定植和感染。我们的目标是确定从阴道分泌物中分离出的酵母菌在孕妇中的患病率及其对当前抗真菌药物的敏感性。1998年12月至2000年2月期间共研究了493例患者。念珠菌属的患病率为28%（白色念珠菌90.4%；光滑念珠菌6.3%；近平滑念珠菌1.1%，克柔念珠菌1.1%；未鉴定的菌种1.1%）。采用沙多米琼脂扩散试验来确定对氟康唑、酮康唑、伊曲康唑和制霉菌素的敏感性。所有白色念珠菌、克柔念珠菌和近平滑念珠菌分离株在体外对所测试的抗真菌药物敏感，而每6株光滑念珠菌分离株中有1株对唑类药物耐药；所有菌株对制霉菌素敏感。在孕妇中，白色念珠菌是最常从阴道分泌物中分离出的酵母菌；它对抗真菌药物仍然高度敏感。仅在光滑念珠菌分离株中检测到唑类耐药。建议进行菌种鉴定，特别是在治疗失败以及复发性或慢性感染的情况下。
