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碳纳米管:用于药物化学和生物技术应用的材料。

Carbon nanotubes: materials for medicinal chemistry and biotechnological applications.

作者信息

Pagona Georgia, Tagmatarchis Nikos

机构信息

Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vass. Constantinou Ave., Athens 116 35, Greece.

出版信息

Curr Med Chem. 2006;13(15):1789-98. doi: 10.2174/092986706777452524.

Abstract

Carbon nanotubes are considered as molecular wires exhibiting novel properties for diverse applications including medicinal and biotechnological purposes. Surface chemistry on carbon nanotubes results on their solubilization in organic solvents and/or aqueous/physiological media. Herein, we will present how interfacing such novel carbon-based nanomaterials with biological systems may lead to new applications in diagnostics, vaccine and drug delivery. Recent developments in this rapidly growing field will be presented thus suggesting exciting opportunities for the utilization of carbon nanotubes as useful tools for biotechnological applications. Emphasis will be placed in the integration of biomaterials with carbon nanotubes, which enables the use of such hybrid systems as biosensor devices, immunosensors and DNA-sensors.

摘要

碳纳米管被视为具有新颖特性的分子导线,可用于包括医学和生物技术目的在内的多种应用。碳纳米管的表面化学性质使其能够溶解于有机溶剂和/或水性/生理介质中。在此,我们将阐述将此类新型碳基纳米材料与生物系统相结合如何能在诊断、疫苗和药物递送方面带来新的应用。本文将介绍这一快速发展领域的最新进展,从而表明利用碳纳米管作为生物技术应用的有用工具具有令人兴奋的机会。重点将放在生物材料与碳纳米管的整合上,这使得此类混合系统能够用作生物传感器装置、免疫传感器和DNA传感器。

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