Jarman Simon N
Department of the Environment and Heritage, Australian Antarctic Division, 203 Channel Highway, Kingston, TAS, 7050, Australia.
Bioinformatics. 2006 Sep 1;22(17):2160-1. doi: 10.1093/bioinformatics/btl330. Epub 2006 Jun 20.
Cleaver is an application for identifying restriction endonuclease recognition sites that occur in some taxa but not in others. Differences in DNA fragment restriction patterns among taxa are the basis for many diagnostic assays for taxonomic identification and are used in procedures for removing the DNA of some taxa from pools of DNA from mixed sources. Cleaver analyses restriction digestion of groups of orthologous DNA sequences simultaneously to allow identification of differences in restriction pattern among the fragments derived from different taxa.
Cleaver is freely available without registration from its website (http://cleaver.sourceforge.net/) and can be copied, modified and re-distributed under the terms of the GNU general public licence version2 (http://www.gnu.org/licences/gpl). The program can be run as a script for computers that have Python 2.3 and necessary extra modules installed. This allows it to run on Gnu/Linux, Unix, MacOSX and Windows platforms. Stand-alone executable versions for Windows and MacOSX operating systems are available.
Cleaver是一款用于识别某些分类群中存在而其他分类群中不存在的限制性内切酶识别位点的应用程序。分类群之间DNA片段限制性模式的差异是许多分类鉴定诊断分析的基础，并用于从混合来源的DNA池中去除某些分类群的DNA的程序中。Cleaver同时分析直系同源DNA序列组的限制性消化，以识别源自不同分类群的片段之间限制性模式的差异。
Cleaver可从其网站（http://cleaver.sourceforge.net/）免费获取，无需注册，并且可以根据GNU通用公共许可证第2版（http://www.gnu.org/licences/gpl）的条款进行复制、修改和重新分发。该程序可以作为脚本在安装了Python 2.3和必要的额外模块的计算机上运行。这使其能够在Gnu/Linux、Unix、MacOSX和Windows平台上运行。有适用于Windows和MacOSX操作系统的独立可执行版本。
