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用降钙素治疗颞骨巨细胞修复性肉芽肿。

Giant cell reparative granuloma of the temporal bone treated with calcitonin.

作者信息

Souter Melanie A, Bird Philip A, Worthington Jim P

机构信息

Department of Otolaryngology, Christchurch Hospital, Christchurch, New Zealand.

出版信息

Otol Neurotol. 2006 Oct;27(7):999-1002. doi: 10.1097/01.mao.0000224076.54978.f0.

Abstract

OBJECTIVE

A case report of a giant cell reparative granuloma involving the temporal bone successfully treated with calcitonin.

STUDY DESIGN

Case report.

SETTING

Teaching hospital, tertiary referral center.

PATIENT, INTERVENTION, AND RESULTS: A 62-year-old man was referred to the otolaryngology department with an extensive temporal bone lesion confirmed by biopsy to be a giant cell reparative granuloma. As an alternative to surgery, calcitonin therapy was commenced. After 12 months of treatment, clinical and audiological parameters had returned to normal, and radiological appearances had shown significant bony remodeling. These parameters remain stable 24 months after cessation of treatment.

CONCLUSION

Calcitonin is a safe and economical medical treatment, which should be considered for destructive giant cell granulomas of the temporal bone.

摘要

目的

报告1例用降钙素成功治疗的累及颞骨的巨细胞修复性肉芽肿病例。

研究设计

病例报告。

研究地点

教学医院,三级转诊中心。

患者、干预措施及结果:一名62岁男性因广泛的颞骨病变被转诊至耳鼻喉科,活检证实为巨细胞修复性肉芽肿。作为手术替代方案,开始降钙素治疗。治疗12个月后,临床和听力学参数恢复正常,影像学表现显示有明显的骨质重塑。停止治疗24个月后,这些参数保持稳定。

结论

降钙素是一种安全且经济的药物治疗方法,对于颞骨破坏性巨细胞肉芽肿应予以考虑。

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