Kroese-Deutman H C, Wolke J G C, Spauwen P H M, Jansen J A
Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands.
J Biomed Mater Res A. 2006 Dec 1;79(3):503-11. doi: 10.1002/jbm.a.30805.
Calcium phosphate (Ca-P) cement is a well established material for bone repair. The bone biological properties of Ca-P cement can even be further improved by creating porosity in the material. The current study aimed on the evaluation of the osteoconductive behavior of porous Ca-P cement. Therefore, circular defects (6, 9, and 15 mm in diameter) were created in the cranium of 3 months old rabbits and filled with porous Ca-P cement implants. The total porosity of implants was calculated to be 71, 74 and 74% respectively and the average pore diameter was 150 microm. In addition, empty control defects were prepared. After 12 weeks implantation time the animals were sacrificed and radiographic, histological, and histomorphometrical evaluation was performed. The Critical Size Defect (CSD) of this species at this location for an implantation time of 12 weeks was confirmed to be 15 mm. Bone was observed to be present over and through almost all porous Ca-P cement implants. Only, in one out of eight animals with a 15 mm implant complete bone bridging of the defect did not occur. The size of the defect was found not to affect the total percentage of bone formation in the cement; (17 +/- 7)%, (18 +/- 6)% and (17 +/- 3)% for respectively 6, 9, and 15 mm diameter implants. We concluded that porous Ca-P cement is an excellent osteoconductive material in non weight bearing situations and complete bridging of a critical sized skull defect occurs in this rabbit model after 12 weeks of implantation.
磷酸钙（Ca-P）骨水泥是一种成熟的骨修复材料。通过在材料中制造孔隙，Ca-P骨水泥的骨生物学性能甚至可以进一步提高。当前的研究旨在评估多孔Ca-P骨水泥的骨传导行为。因此，在3个月大的兔子颅骨上制造圆形缺损（直径分别为6、9和15毫米），并用多孔Ca-P骨水泥植入物填充。植入物的总孔隙率分别计算为71%、74%和74%，平均孔径为150微米。此外，还制备了空白对照缺损。植入12周后处死动物，并进行放射学、组织学和组织形态计量学评估。该物种在该位置植入12周时的临界尺寸缺损（CSD）被确认为15毫米。观察到几乎所有多孔Ca-P骨水泥植入物上及内部都有骨存在。只有在植入15毫米植入物的八只动物中的一只中，缺损没有完全被骨桥接。发现缺损大小不影响骨水泥中骨形成的总百分比；直径分别为6、9和15毫米的植入物的骨形成总百分比分别为（17±7）%、（18±6）%和（17±3）%。我们得出结论，多孔Ca-P骨水泥在非负重情况下是一种优秀的骨传导材料，在该兔模型中植入12周后，临界尺寸的颅骨缺损会完全被骨桥接。
