涉及有机锌以及混合有机铜/有机锌试剂的自由基-极性交叉多米诺反应。

Radical-polar crossover domino reactions involving organozinc and mixed organocopper/organozinc reagents.

作者信息

Denes Fabrice, Cutri Sabrina, Perez-Luna Alejandro, Chemla Fabrice

机构信息

Université Pierre et Marie Curie - Paris 6, Laboratoire de chimie organique (UMR CNRS 7611), Institut de chimie moléculaire (FR 2769) case 183, 4 place Jussieu, 75252 Paris cedex 05, France.

出版信息

Chemistry. 2006 Aug 25;12(25):6506-13. doi: 10.1002/chem.200600334.

DOI:10.1002/chem.200600334

PMID:16789032

Abstract

A domino process involving Michael addition and carbocyclization has been developed starting from beta-N-allylamino enoates and various organometallic reagents (organozinc halides, diorganozinc reagents, and copper/zinc mixed species). In all cases the mechanism of this domino reaction has been evidenced to involve a radical-polar crossover mechanism.

摘要

一种从β-N-烯丙基氨基烯酸酯和各种有机金属试剂（有机卤化锌、二有机锌试剂以及铜/锌混合物种）出发的、涉及迈克尔加成和碳环化的多米诺反应已经被开发出来。在所有情况下，这种多米诺反应的机理已被证明涉及自由基-极性交叉机理。