使用非甾体抗炎药研究前列腺素在大鼠胃黏膜中的血管舒张和抗分泌作用。
Investigation of the vasodilator and antisecretory role of prostaglandins in the rat gastric mucosa by use of non-steroidal anti-inflammatory drugs.
作者信息
Main I H, Whittle B J
出版信息
Br J Pharmacol. 1975 Feb;53(2):217-24. doi: 10.1111/j.1476-5381.1975.tb07351.x.
Abstract
1 The effects of non-steroidal anti-inflammatory drugs on gastric acid secretion and mucosal blood flow were studied in the rat. 2 Indomethacin, in ulcerogenic doses, caused a dose-dependent rise in pentagastrin-stimulated acid secretion, but decreased mucosal blood flow per unit acid secretion. 3 During resting conditions, indomethacin had no significant effect on acid output, but reduced mucosal blood flow. 4 Pretreatment with indomethacin, phenylbutazone or meclofenamate potentiated the secretory response to dibutyryl cyclic adenosine 3',5'-monophosphate. 5 Indomethacin markedly reduced the mucosal prostaglandin-like activity at a time when mucosal erosion formation had reached steady levels. 6 These results provide evidence that prostaglandins have a local role in the regulation of blood flow and acid secretion in the rat gastric mucosa, and suggest that non-steroidal anti-inflammatory drugs cause mucosal erosions by disrupting these processes.
摘要
- 在大鼠中研究了非甾体抗炎药对胃酸分泌和黏膜血流的影响。2. 致溃疡剂量的吲哚美辛导致五肽胃泌素刺激的胃酸分泌呈剂量依赖性升高，但单位胃酸分泌的黏膜血流减少。3. 在静息状态下，吲哚美辛对胃酸分泌无显著影响，但会减少黏膜血流。4. 用吲哚美辛、保泰松或甲氯芬那酸预处理可增强对二丁酰环磷腺苷3',5'-单磷酸的分泌反应。5. 当黏膜糜烂形成达到稳定水平时，吲哚美辛显著降低了黏膜前列腺素样活性。6. 这些结果证明前列腺素在大鼠胃黏膜血流和胃酸分泌的调节中具有局部作用，并表明非甾体抗炎药通过破坏这些过程导致黏膜糜烂。
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