花生四烯酸对大鼠胃酸分泌的影响（针对不同促分泌剂）；吲哚美辛对这些影响的抑制作用
Effects of arachidonic acid on rat gastric acid secretion in response to different secretogogues; inhibition of these effects by indomethacin.
作者信息
Frame M H, Main I H
出版信息
Br J Pharmacol. 1980 Jun;69(2):171-8. doi: 10.1111/j.1476-5381.1980.tb07887.x.
1 The effects of the prostaglandin precursor, arachidonic acid, and the non-steroidal anti-inflammatory drug, indomethacin, on gastric acid secretion were studied in the rat, in vivo and in vitro. Gastric mucosal blood flow was also measured in vivo. 2 Arachidonate produced significant inhibition of acid secretion stimulated by pentagastrin or histamine. It did not significantly affect dibutyryl cyclic adenosine 3',5'-monophosphate (db cyclic AMP)-induced acid secretion. 3 Inhibition of acid secretion by arachidonate was accompanied by a rise in the ratio of mucosal blood flow to acid secretion. 4 Indomethacin did not significantly alter histamine- or pentagastrin-induced acid secretion. 5 In the presence of indomethacin, the inhibitory effect of arachidonate was significantly reduced. 6 These results provide evidence that the rat gastric mucosa is capable of synthesizing, from exogenous precursor, products of cyclo-oxygenase which inhibit gastric acid secretion.
在大鼠体内和体外研究了前列腺素前体花生四烯酸以及非甾体抗炎药吲哚美辛对胃酸分泌的影响。同时也在体内测量了胃黏膜血流量。
花生四烯酸盐对五肽胃泌素或组胺刺激的胃酸分泌产生显著抑制作用。它对二丁酰环磷腺苷（db 环磷酸腺苷）诱导的胃酸分泌没有显著影响。
花生四烯酸盐对胃酸分泌的抑制伴随着黏膜血流量与胃酸分泌比值的升高。
吲哚美辛对组胺或五肽胃泌素诱导的胃酸分泌没有显著改变。
在吲哚美辛存在的情况下，花生四烯酸盐的抑制作用显著降低。
这些结果证明大鼠胃黏膜能够从外源性前体合成环氧化酶产物，这些产物可抑制胃酸分泌。
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