E 型和 A 型前列腺素对大鼠胃黏膜血流及胃酸分泌的影响。
The effects E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat.
作者信息
Main I H, Whittle B J
出版信息
Br J Pharmacol. 1973 Nov;49(3):428-36. doi: 10.1111/j.1476-5381.1973.tb17253.x.
Abstract
- The effects of prostaglandins E(1), E(2), A(1) and A(2) on gastric acid secretion and mucosal blood flow were studied by means of a [(14)C]-aniline clearance technique in the anaesthetized rat.2. During intravenous administration of these prostaglandins, in doses which almost completely inhibited pentagastrin- and histamine-induced acid secretion, a fall in clearance was observed.3. Clearance per unit acid secretion increased during prostaglandin administration, precluding a primary reduction in mucosal blood flow as the mechanism of the antisecretory action.4. Prostaglandins increased clearance during basal secretion, indicating a direct vasodilator effect on the gastric mucosa.5. The possibility that endogenous prostaglandins contribute to functional vasodilatation in the gastric mucosa and that exogenous prostaglandins may be of clinical value in the treatment of peptic ulcer is discussed.
摘要
采用[¹⁴C]-苯胺清除技术，在麻醉大鼠中研究了前列腺素E(1)、E(2)、A(1)和A(2)对胃酸分泌和黏膜血流的影响。
在静脉注射这些前列腺素期间，当剂量几乎完全抑制五肽胃泌素和组胺诱导的胃酸分泌时，观察到清除率下降。
在给予前列腺素期间，单位胃酸分泌的清除率增加，排除了黏膜血流的原发性减少作为抗分泌作用机制的可能性。
前列腺素在基础分泌期间增加清除率，表明对胃黏膜有直接的血管舒张作用。
讨论了内源性前列腺素促成胃黏膜功能性血管舒张的可能性，以及外源性前列腺素在消化性溃疡治疗中可能具有临床价值。
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